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- W2359658568 abstract "To study the effects of terminal complement complex C5b-9 on maturation and function dendritic cells in vitro,im- mature dendritic cells were induced from monocytes with rhGM-CSF and rhIL-4.C5b-9 treated immature dendritic cells were incubated for 96 hours,and then the immune phenotype and antigen uptake activity were determined by using flow cytometry. T cell stimulating activity was analyzed by allo-MLR.Cytokines were analyzed by ELISA.Compared with the control,cell surface marker of C5b-9 treated DC,such CD83,HLA,CD80,CD86,B7-H1,B7-H3,B7-H4,BTLA was signifi- cant up-regulated.Cytokine secretion was increased while antigen uptake activity was decreased.The activity of promoting CD4~+ T cells activation and proliferation was increased,at the same time IL-2 and IFN-γsecretion was promoted.It is conclu- ded that terminal complements complex C5b-9 link innate and adaptive immune responses through promoting DC maturation." @default.
- W2359658568 created "2016-06-24" @default.
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- W2359658568 date "2007-01-01" @default.
- W2359658568 modified "2023-09-25" @default.
- W2359658568 title "Terminal complement complex C5b-9 promotes maturation of human monocyte-derived dendritic cells" @default.
- W2359658568 hasPublicationYear "2007" @default.
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