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- W2359673863 abstract "Objective Severe dysplasia is considered as an important precancerous lesion in the upper digestive tract and there is lack of an effective and simple treatment for those lesions. The purpose of this study was to explore the possibilities and feasibility of NdYAG laser ablation of severe dysplasia in the upper digestive tract and its significance in cancer prevention. Methods Thirty patients with severe dysplasia of squamous epithelium of the esophagus and columnal epithelium of the gastric cardia or stomach were included in this study. There were 20 males and 10 females, aged 3068 years with an average of 45 years. All lesions were diagnosed during endoscopy and confirmed by histopathology of biopsies. The lesions were endoscopically classified as erosive type in 15, conjestive in 6, slightly protruding in 5 and shallow ulcerative in 4 cases. All patients gave informed concent prior to therapy and were treated in the outpatient department. 10 ml of physiological saline was injected, prior to the laser irradiation, into the submucosa to make the lesion swollen and protruded. It may very well prevent a possible perforation caused by serious photodamage to the deeper parts of the wall of the organs. The laser coagulation or vaporization was performed at a power of 30 W and the tip of optical fiber was kept at a distance of 0.51.0 cm from the lesions. Results All patients were endoscopically examined at one month after the treatment. A normal appearance of the mucosa was restored and no dysplasia was revealed by histopathology. 26 cases (86.7%) with lesions smaller than 1.5 cm1.5 cm were cured after one treatment and the 4 cases (13.3%) with lesions greater than 1.5 cm1.5 cm were cured after the second treatment. The total cure rate was 100%. No ev ident side effects or complications such as perforation, bleeding or stenosis occurred. Conclusions Our results demonstrated that NdYAG laser ablation may be an effective, safe, simple to operate, economic and minimally discomfortable treatment for severe dysplasia in the upper digestive tract." @default.
- W2359673863 created "2016-06-24" @default.
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- W2359673863 date "1999-01-01" @default.
- W2359673863 modified "2023-09-23" @default.
- W2359673863 title "NdYAG Laser Ablation of Severe Dysplasia in the Upper Digestive Tract" @default.
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