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- W2359674015 abstract "Objective To investigate the changes of tissue factor(TF) expression of monocytes(Mo) during the onset of acute myocardial in farction(AMI) and acute ischemic stroke(AIS).Methods(1)The expressions of Mo TF mRNA in 20 AMI patients,20 AIS patients and 61 normal controls were tested,semiquantity reverse transcriptase-polymerase chain reaction(RT-PCR) was used.(2) By means of chroMogenic substrate and ELISA,the levels of TF act and TFAg in plasma were detected in 40 AMI and 46 AIS patients at onset phase,84 age- matched healthy volunteers respectively.Results(1) Compared with the control group,the expressions of Mo TFmRNA were significantly higher in AMI and AIS groups.(2) Compared with the control group,plasma TF activity was higher in AMI,but not statistically difference,but TF antigens was significantly higher in AMI group;plasma TF activity and antigen in AIS group were significantly increased. (3)TF activity and TF antigen were significantly associated with the expression of Mo TF mRNA.Conclusions (1)The expression of TF mRNA in Mo was upregulation during the onset of AMI and AIS.(2) During the onset of AMI and AIS,the initiation of tissue factor pathway was associated with the cerebrocardiac thrombotic events and that the high level of TF antigens in plasma was the com Mo feaure." @default.
- W2359674015 created "2016-06-24" @default.
- W2359674015 creator A5023692438 @default.
- W2359674015 date "2009-01-01" @default.
- W2359674015 modified "2023-09-26" @default.
- W2359674015 title "Observation on Tissue Factor Expression of Monocytes in Patients with Acute Cerebrocardiac Thrombotic Diseases" @default.
- W2359674015 hasPublicationYear "2009" @default.
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