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- W2359675101 abstract "Objective To investigate the growth inhibiting and apoptosis inducing effect of saikosaponin-d (SSd)on retinoblastoma cells(RBCs),and the mechanism of its signal transduction.Methods The inhibitory effect of SSd on cell growth was detected by ~3H-thymine incorporation method,the influence of SSd on Y79 cell cy- cle was determined by flow cytometry,cells apoptosis was detected by DNA fragmentation analysis using gel elec- trophoresis,phosphorylation of p38 was analyzed by Western blot.Results SSd showed significant inhibitory effect on Y79 cell growth.After the Y79 cells being treated with 10μg/ml SSd for 9 hrs,its ~3H-thymine incorporation rate decreased to 55.15% and cell apoptosis could be induced by SSd.And p38 was activated i.e.phosphorylated during the procedure.Conclusion SSd could not only inhibit cell growth but also induce apoptosis of Y79 cells, and the process is mediated by p38 phosphorylation." @default.
- W2359675101 created "2016-06-24" @default.
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- W2359675101 date "2005-01-01" @default.
- W2359675101 modified "2023-09-26" @default.
- W2359675101 title "Apoptosis of Retinoblastoma Cells Induced by Saikosaponin-d via Phosphorylation of P38" @default.
- W2359675101 hasPublicationYear "2005" @default.
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