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• W2359687524 abstract "Objective:To observe the efficiency and safety for labor pain using combined spinal-epidural analgesia with three drug on mother and fetus, and to find out the best compatibility and dosage of medicine to relief labor pain.Methods:300 parturients were randomized into three experiment groups, including ropivacaine group (group R), sufentanil group (group S) and group of ropivacaine plus fentanyl (group RF). Another 100 delivery woman without any analgesics was chosen as control group. Analgesic effect on mother and newborn were observed and recorded.Results:①Analgesic potency comparison: Good analgesic effects were obtained in all three analgesic groups. The onset of analgesia in group RF and group S were significantly faster than that in group R (P0.01). The anesthetic duration of first dosage was significantly longer in group PF and group S than that in group R (P0.01). There was no significant difference between group RF and group S (P0.05) and the total dose of local anesthetic in group RF was significant less than that in group R (P0.01). ②The influence on parturients: No significant difference in MBP (mean arterial blood pressure), HR (heart rate), RR (respiration rate), SpO2 (saturation oxygen) were found in all the three experiment analgesic groups measured in various points before and after analgesia (P0.05).③The influence on the duration of labor process: The first stage in the three analgesia groups was shorter than that in control group (P0.01). There were no significant differences in the duration of the second and third stage among all of groups. No significant difference was found in all the four groups dealing with the assistance of surgical instruments. ④The influence on newborn: There were no significant difference in 1st min and 5th min Apgar score among the four groups(P0.05). ⑤The incidence of adverse effects: There were 12 cases in group S and 17 cases in group RF showing skin itch, and no symptom needed to cure. No significant difference of other adverse effects were found among the four groups (P0.05).Conclusion:All the three of analgesic plans were safe and efficient for labor pain. The group received combined spinal-epidural analgesia with 0.15% ropivacaine plus fentanyl 2 μg/ml showed better labor analgesia, faster onset time, longer duration, less total dose, and lighter motor block, because this combination had less side effects, easier reception for parturients with higher satisfaction rate, being an ideal painless way of labor." @default.
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• W2359687524 date "2007-01-01" @default.
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• W2359687524 title "Comparison of drug of combined spinal-epidural analgesia for labor pain" @default.
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