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- W2359690411 abstract "Objective To investigate the clinical significance of p16 protein expression in the diagnosis,histological grading and prognosis of chondrosarcoma. Methods p16 expression was studied in paraffin sections of chondrosarcoma by immunohistochemical (S-P) assay,and DNA ploidy was measured by flow cytometry. Results (1) p16 protein expression showed significant correlation with his-tologic grades of chondrosarcoma (P0.05). (2) Normal cartilaginous tissue,benign cartilaginous tumor, and low grade (grade Ⅰ and grade Ⅱ) chondrosarcoma were mainly diploid. High grade (grade Ⅲ) chondrosarcoma was aneuploid. The higher p16 protein expressed, the less DNA aneuploid presented. p16 expression showed a significant direct correlation with DNA aneuploid (r=0.925,P 0.05). (3) There were statistical significances (P0.05) in comparing the differences between p16 protein expression and tumor size and recurrence. Couclusion p16 protein expression is of some guiding significance in histologic grading,malignant development and prognostic assessment for chondrosarcoma." @default.
- W2359690411 created "2016-06-24" @default.
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- W2359690411 date "2003-01-01" @default.
- W2359690411 modified "2023-09-25" @default.
- W2359690411 title "Clinical significance of p16 expression and DNA ploidy in chondrosarcoma" @default.
- W2359690411 hasPublicationYear "2003" @default.
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