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- W2359690828 abstract "Objective To investigate the effect of Fas and FasL abnormal expression on immune escape mechanism of renal cell carcinoma(RCC). Methods The expression of Fas and FasL was detected in 44 cases of RCC and 10 cases of normal kidney tissue by immunohistochemical method. Tumor infiltrating T lymphocyte's apoptosis in 44 cases of RCC was examined by TUNEL assay. FCM was used to detect the expression of Fas and FasL as well as apoptosis in RCC cell line 786-0. In addition, the apoptosis of Jurkat T cell with Fas exprssion was also analysed with FCM. Results Fas expression rate (22.8%) in RCC was significantly lower than that (53.8%) in normal kidney tissue(P0.01), while FasL expression rate (46.5%) in RCC was significantly higher than that (23.5%) in normal kidney tissue. The negative correlation between Fas and FasL expression was found in RCC(r=-0.46,P0.05), and the apoptotic rate of tumor infiltrating T lymphocyte was positively associated with FasL expression in RCC(r=0.96,P0.01). Chemotherapeutic drug 5-Fu could increase the cytotoxic effect of anti-Fas mAb(CH11) on RCC cell line 786-0 by up-regulating Fas expression, and decrease the cytotoxic effect of RCC cell line 786-0 on Jurkat T lymphocyte by down-regulating FasL expression. Conclusion Immune escape mechanism of RCC included escaping the cytotoxic effect of anti-Fas mAb by down-regulating Fas expression, and enhancing its ability for attacking T lymphocyte by up-regulating FasL expression. Chemotherapeutic drug 5-Fu had a certain therapeutic effect on RCC by increasing Fas expression and decreasing the FasL expression in RCC." @default.
- W2359690828 created "2016-06-24" @default.
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- W2359690828 date "2005-01-01" @default.
- W2359690828 modified "2023-09-27" @default.
- W2359690828 title "The Effect of Fas and FasL Abnormal Expression on Immune Escape Mechanism of Renal Cell Carcinoma" @default.
- W2359690828 hasPublicationYear "2005" @default.
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