Matches in SemOpenAlex for { <https://semopenalex.org/work/W2359692024> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2359692024 abstract "Objective An solid-phase-extraction ion chromatography was developed for determining three residual impurities such as acetic acid(MCAA),dichloroacetic acid(DCAA) and chloride ion(Cl-) in crude oligonucleotide simultaneously.Methods The final optimized conditions for testing were listed as follows by using Ionpac AS 23(4 mm×250 mm) analytical column,Ionpac AG23(4 mm×50 mm) protective column,mobile phase as 0.8 mmol·L-1 NaHCO3/4.5 mmol·L-1 Na2CO3 and suppressed conductivity detector.Results The standard curve equation of MCAA,DCAA and Cl-were Y= 5.230 7X+0.014(r=0.999 7),Y=19.762X-0.007 2(r=0.999 9) and Y=507.4X-0.746 2(r=0.999 8),respectively;MCAA,DCAA and Cl-showed a good linearity in 0.002-0.400 μg·mL-1,0.000 624-0.156 μg·mL-1,0.002 4-1.5 mg·mL-1 and detection limits were 0.02,0.312 ng·mL-1 and 0.01 μg · mL-1,respectively.Conclusion The method is simple,fast,accuracy and can be used for impurities control of crude oligonucleotide." @default.
- W2359692024 created "2016-06-24" @default.
- W2359692024 creator A5033187226 @default.
- W2359692024 date "2012-01-01" @default.
- W2359692024 modified "2023-09-25" @default.
- W2359692024 title "Determination of Impurities in the Oligonucleotide by Solid Phase Extraction Ionchromatography" @default.
- W2359692024 hasPublicationYear "2012" @default.
- W2359692024 type Work @default.
- W2359692024 sameAs 2359692024 @default.
- W2359692024 citedByCount "0" @default.
- W2359692024 crossrefType "journal-article" @default.
- W2359692024 hasAuthorship W2359692024A5033187226 @default.
- W2359692024 hasConcept C113196181 @default.
- W2359692024 hasConcept C119128265 @default.
- W2359692024 hasConcept C178790620 @default.
- W2359692024 hasConcept C185592680 @default.
- W2359692024 hasConcept C206967267 @default.
- W2359692024 hasConcept C2776673659 @default.
- W2359692024 hasConcept C2777616060 @default.
- W2359692024 hasConcept C2778695967 @default.
- W2359692024 hasConcept C43617362 @default.
- W2359692024 hasConcept C4725764 @default.
- W2359692024 hasConcept C55493867 @default.
- W2359692024 hasConcept C71987851 @default.
- W2359692024 hasConcept C81426234 @default.
- W2359692024 hasConceptScore W2359692024C113196181 @default.
- W2359692024 hasConceptScore W2359692024C119128265 @default.
- W2359692024 hasConceptScore W2359692024C178790620 @default.
- W2359692024 hasConceptScore W2359692024C185592680 @default.
- W2359692024 hasConceptScore W2359692024C206967267 @default.
- W2359692024 hasConceptScore W2359692024C2776673659 @default.
- W2359692024 hasConceptScore W2359692024C2777616060 @default.
- W2359692024 hasConceptScore W2359692024C2778695967 @default.
- W2359692024 hasConceptScore W2359692024C43617362 @default.
- W2359692024 hasConceptScore W2359692024C4725764 @default.
- W2359692024 hasConceptScore W2359692024C55493867 @default.
- W2359692024 hasConceptScore W2359692024C71987851 @default.
- W2359692024 hasConceptScore W2359692024C81426234 @default.
- W2359692024 hasLocation W23596920241 @default.
- W2359692024 hasOpenAccess W2359692024 @default.
- W2359692024 hasPrimaryLocation W23596920241 @default.
- W2359692024 hasRelatedWork W134990333 @default.
- W2359692024 hasRelatedWork W146353736 @default.
- W2359692024 hasRelatedWork W1937001562 @default.
- W2359692024 hasRelatedWork W2010086028 @default.
- W2359692024 hasRelatedWork W2023075353 @default.
- W2359692024 hasRelatedWork W2023700440 @default.
- W2359692024 hasRelatedWork W2046359532 @default.
- W2359692024 hasRelatedWork W2134840092 @default.
- W2359692024 hasRelatedWork W2160358298 @default.
- W2359692024 hasRelatedWork W2325958590 @default.
- W2359692024 hasRelatedWork W2353167778 @default.
- W2359692024 hasRelatedWork W2364334755 @default.
- W2359692024 hasRelatedWork W2373487548 @default.
- W2359692024 hasRelatedWork W2380674570 @default.
- W2359692024 hasRelatedWork W239875833 @default.
- W2359692024 hasRelatedWork W2410983063 @default.
- W2359692024 hasRelatedWork W3024657079 @default.
- W2359692024 hasRelatedWork W3046537251 @default.
- W2359692024 hasRelatedWork W3109348223 @default.
- W2359692024 hasRelatedWork W3181402084 @default.
- W2359692024 isParatext "false" @default.
- W2359692024 isRetracted "false" @default.
- W2359692024 magId "2359692024" @default.
- W2359692024 workType "article" @default.