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- W2359694911 abstract "Objective To construct tissue engineering neocartialge based on the modified polylactic acid(PLA) scaffold with hyaluronic acid(HA).The significance of HA in construct tissue-engineered cartilage was to be analyzed and discussed.Methods The highly porous PLA scaffold was made by salt-leaching method;Low concentration NaOH,carbodiimide and HA were used to modify the scaffold.The third passage of chondrocytes was seeded into the scaffold after prewetted.The concentration was 5×107 per milliliter.The complex was implanted into rabbits one week after vitro culture.The prepared complex was implanted into the back of the New Zealand rabbits.The complexes of chondrocyte-modified PLA scaffold were applied in the experimental group,and the complexes of chondrocyte-PLA scaffold were used in the control group.Two rabbits were sacrificed randomly at four,six,eight weeks after implantation.The tissue were taken out according to the marker made during operation at 4,6,8 weeks after operation respectively.The histological characteristics was observed by HE,Masson,toluidine blue stain and typeⅡcollagen immunohistochemical test.Results There was no immunoreactive rejection after implantation of the cell-scaffold complex.After two month two kinds of cell-scaffold appearance were similar to the articular cartilage.The results of histochemical test revealed that the tissue had been becoming better when being ompanted longer.A comparison analysis was made according to the expression intensity using Imagej.There were statistical significance between experimental and control groups(P0.05) at 6,8 weeks.The secretion cartilage matrix of modified scaffold group was better than that of the PLA group.Conclusion The allogeneic chondrocytes could be the seed of tissue-engineered cartilage.The modified PLA scaffold can be the carrier to form neocartilage in vivo." @default.
- W2359694911 created "2016-06-24" @default.
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- W2359694911 date "2012-01-01" @default.
- W2359694911 modified "2023-09-24" @default.
- W2359694911 title "Construction of tissue engineering cartilage with modified polylactic acid scaffold using hyaluronic acid" @default.
- W2359694911 hasPublicationYear "2012" @default.
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