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- W2359754896 abstract "Objective: To discuss the adjust mechinism of nitric oxide synthase(NOS) and NF-kappaB(NF-ΚB) in brain and in different time following brain ischemia reperfusion.Methods: A classical animal model of brain ischemia-reperfusion was established by imitation.Seventy-two healthy rats were randomly divided into 9 groups: control group,ischemia 30 min,reperfusion immediatoly after ischemia 30 min,2 hr reperfusion after ischemia 30 min,4 hr reperfusion after ischemia 30 min,6 hr reperfusion after ischemia 30 min,8 hr reperfusion after ischemia 30 min,10 h reperfusion after ischemia 30 min,12 hr reperfusion after ischemia 30 min.The varying of expressing of NOS,NF-κB in different time and different brain tissue including amygdaloid nucleus,paraventricular nucleus,nucleus ceruleus were examined by immune chemical technique.Results: Among 8~10 h group a apart of nueral cell have karyolysis and liquefactive necrosis.Expressing of NOS have apprant ascend trend in I/R0~8 h group.The expression of NOS reached the higest in I/R8 h.The expression of NOS have statistic significance among the I/R0 h,I/R2 h,I/R4 h,(I/R6 h),I/R8 h,I/R10 h,and I/R12 h groups.The expression of NF-κB had statistic significance among(I/R0 h),I/R2 h,I/R4 h,I/R6 h,I/R8 h,I/R4 h,I/R6 h,and I/R8 h groups.Expressing of NF-κB have apprant ascend trend in I/R0-8 h group.Conclusions: NOS and NF-κB may intervene in the chains of the cell injures in ischemia-reperfusion injure of brain.amygdaloid nucleus,paraventricular nucleus,nucleus ceruleus may participate in regulative effect of central nerve systeme.NO had double effect." @default.
- W2359754896 created "2016-06-24" @default.
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- W2359754896 date "2006-01-01" @default.
- W2359754896 modified "2023-09-23" @default.
- W2359754896 title "The expression and singnificance of NOS and NF-κB following acute brain ischemia-reperfusion in rats" @default.
- W2359754896 hasPublicationYear "2006" @default.
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