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- W2359761628 abstract "Objective: To explore the clinical value of cerebrospinal fluid concentration of beta-amyloid protein (Aβ1-42), total tau protein (t-tau), phosphorylated tau protein (p-tau181), as well as Aβ1-42/ t-tau ratio and Aβ1-42/ p-tau181 ratio for the diagnosis of Alzheimer disease (AD) and vascular dementia (VD). Methods: Enzyme-linked immunosorbent assay was used to determine the cerebrospinal fluid concentration of Aβ1-42, t-tau protein and p-tau181 protein in normal control (NC) or patients with AD or VD. Results: The cerebrospinal fluid Aβ1-42 concentration in AD group was lower than that in VD and NC group. In AD group, the concentration of t-tau protein and p-tau181 protein was higher than that in VD and NC group. At an optimal cutoff level of Aβ1-42/ p-tau181 of 11.3, the sensitivity and specificity for the discrimination between AD and VD were 95% and 94%, respectively. Conclusions: Cerebrospinal fluid Aβ1-42, t-tau protein and p-tau181 protein, especially the Aβ1-42/ p-tau181 ratio, are useful biomarkers for the discrimination between AD and VD." @default.
- W2359761628 created "2016-06-24" @default.
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- W2359761628 date "2009-01-01" @default.
- W2359761628 modified "2023-09-26" @default.
- W2359761628 title "Value of Cerebrospinal Fliud beta-amyloid Protein/Phosphorylated Tau Protein Ratio on Differential Diagnosis of Alzheimer Disease and Vascular Dementia" @default.
- W2359761628 hasPublicationYear "2009" @default.
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