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- W2359763496 abstract "[Objective]To study effect of oxymatrine on d-galactosamine-induced hepatocyte apoptosis.[Methods]The optimalizing parameters of d-galactosamine(d-GalN)-induced hepatocyte apoptosis were determined and then the model of cell apoptosis induced by d-GalN was established in human cell line HL-7702 hepatocytes.The anti-apoptotic effect of oxymatrine was evaluated by using the model established.[Result] The incubation with 60 mmol / L d-GalN for 8 hours may be the optimized conditions of hepatocyte apoptosis induced by d-GalN.Typical apoptosis ladder was observed at 6 h after the HL-7702 hepatocytes were incubated with 60 mmol / L d-GalN.Also the caspase-3,AST,ALT and MDA levels of the d-GalN-sensitized hepatocytes were significantly elevated.[Conclusion]HL-7702 hepatocyte apoptosis induced by d-GalN is probably associated with the mitochondrial pathway.Additionally,oxymatrine exhibited significant inhibition on d-GalN-induced hepatocyte apoptosis and its anti-apoptotic effect may contribute to the inhibition on apoptosis induce factors(Caspases-3,CytC,TNFα and TGF-β1) and induction of anti-apoptotic cytokine heme oxygenase-1(HO-1)." @default.
- W2359763496 created "2016-06-24" @default.
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- W2359763496 date "2013-01-01" @default.
- W2359763496 modified "2023-09-24" @default.
- W2359763496 title "Effect of Oxymatrine on D-Galactosamine-induced Hepatocyte Apoptosis" @default.
- W2359763496 hasPublicationYear "2013" @default.
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