Matches in SemOpenAlex for { <https://semopenalex.org/work/W2359778323> ?p ?o ?g. }
- W2359778323 abstract "Reconstruction of transcriptome by de novo assembly from next generation sequencing (NGS) short-sequence reads provides an essential mean to catalog expressed genes, identify splicing isoforms, and capture the expression detail of transcripts for organisms with no reference genome available. De novo transcriptome assembly faces many unique challenges, including alternative splicing, variable expression level covering a dynamic range of several orders of magnitude, artifacts introduced by reverse transcription, etc. In the current review, we illustrate the grand strategy in applying De Bruijn Graph (DBG) approach in de novo transcriptome assembly. We further analyze many parameters proven critical in transcriptome assembly using DBG. Among them, k-mer length, coverage depth of reads, genome complexity, performance of different programs are addressed in greater details. A multi-k-mer strategy balancing efficiency and sensitivity is discussed and highly recommended for de novo transcriptome assembly. Future direction points to the combination of NGS and third generation sequencing technology that would greatly enhance the power of de novo transcriptomics study." @default.
- W2359778323 created "2016-06-24" @default.
- W2359778323 creator A5027937292 @default.
- W2359778323 creator A5039106985 @default.
- W2359778323 creator A5040290376 @default.
- W2359778323 creator A5042079141 @default.
- W2359778323 creator A5084581495 @default.
- W2359778323 date "2016-05-14" @default.
- W2359778323 modified "2023-09-22" @default.
- W2359778323 title "De novo assembly of transcriptome from next-generation sequencing data" @default.
- W2359778323 cites W1805019014 @default.
- W2359778323 cites W1929898721 @default.
- W2359778323 cites W1936666270 @default.
- W2359778323 cites W1947475265 @default.
- W2359778323 cites W1965100590 @default.
- W2359778323 cites W1966822396 @default.
- W2359778323 cites W1970156673 @default.
- W2359778323 cites W1971031277 @default.
- W2359778323 cites W1974640383 @default.
- W2359778323 cites W1975912699 @default.
- W2359778323 cites W1979662111 @default.
- W2359778323 cites W1981509058 @default.
- W2359778323 cites W1981849943 @default.
- W2359778323 cites W1982717654 @default.
- W2359778323 cites W1984708728 @default.
- W2359778323 cites W1987545661 @default.
- W2359778323 cites W1990199220 @default.
- W2359778323 cites W1990210083 @default.
- W2359778323 cites W1994095434 @default.
- W2359778323 cites W1994154030 @default.
- W2359778323 cites W1996370379 @default.
- W2359778323 cites W1999780947 @default.
- W2359778323 cites W2005129098 @default.
- W2359778323 cites W2011657487 @default.
- W2359778323 cites W2011920499 @default.
- W2359778323 cites W2012016911 @default.
- W2359778323 cites W2015063199 @default.
- W2359778323 cites W2017096350 @default.
- W2359778323 cites W2019208141 @default.
- W2359778323 cites W2022348197 @default.
- W2359778323 cites W2027455260 @default.
- W2359778323 cites W2028384803 @default.
- W2359778323 cites W2029155007 @default.
- W2359778323 cites W2031212650 @default.
- W2359778323 cites W2034573835 @default.
- W2359778323 cites W2035058958 @default.
- W2359778323 cites W2038385990 @default.
- W2359778323 cites W2041391522 @default.
- W2359778323 cites W2042869111 @default.
- W2359778323 cites W2043349549 @default.
- W2359778323 cites W2043714862 @default.
- W2359778323 cites W2044837620 @default.
- W2359778323 cites W2046594687 @default.
- W2359778323 cites W2048798887 @default.
- W2359778323 cites W2050163545 @default.
- W2359778323 cites W2054421148 @default.
- W2359778323 cites W2055260691 @default.
- W2359778323 cites W2060842569 @default.
- W2359778323 cites W2061680337 @default.
- W2359778323 cites W2063206666 @default.
- W2359778323 cites W2063370830 @default.
- W2359778323 cites W2073927977 @default.
- W2359778323 cites W2075155123 @default.
- W2359778323 cites W2076035318 @default.
- W2359778323 cites W2076556926 @default.
- W2359778323 cites W2081046556 @default.
- W2359778323 cites W2083122704 @default.
- W2359778323 cites W2088069070 @default.
- W2359778323 cites W2088862890 @default.
- W2359778323 cites W2092756750 @default.
- W2359778323 cites W2093456070 @default.
- W2359778323 cites W2094448442 @default.
- W2359778323 cites W2096972850 @default.
- W2359778323 cites W2097065948 @default.
- W2359778323 cites W2098531465 @default.
- W2359778323 cites W2099738370 @default.
- W2359778323 cites W2100703845 @default.
- W2359778323 cites W2100867243 @default.
- W2359778323 cites W2101250487 @default.
- W2359778323 cites W2103828958 @default.
- W2359778323 cites W2105371278 @default.
- W2359778323 cites W2106012325 @default.
- W2359778323 cites W2109430663 @default.
- W2359778323 cites W2109701112 @default.
- W2359778323 cites W2110161291 @default.
- W2359778323 cites W2110392562 @default.
- W2359778323 cites W2111618336 @default.
- W2359778323 cites W2111769691 @default.
- W2359778323 cites W2112491476 @default.
- W2359778323 cites W2112888168 @default.
- W2359778323 cites W2114703458 @default.
- W2359778323 cites W2114752404 @default.
- W2359778323 cites W2118276453 @default.
- W2359778323 cites W2118526609 @default.
- W2359778323 cites W2118834857 @default.
- W2359778323 cites W2120597842 @default.
- W2359778323 cites W2126419817 @default.
- W2359778323 cites W2127651281 @default.
- W2359778323 cites W2127768708 @default.
- W2359778323 cites W2127963635 @default.