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- W2359782022 abstract "Objective To explore the expressions of nm23-H1 and PTEN in primary hepatocellular carcinoma(HCC)and their clinicopathological significance.Methods Expressions of nm23-H1 and PTEN protein in liver cancerous tissues and paired para-cancerous tissues of 50 HCC patients were detected by immunohistochemistry.The relationship between the expression levels of nm23-H1、PTEN protein and the clinicopathological parameters of the HCC patients was analyced.Results nm23-H1 and PTEN protein were positively stained in cytoplasm in all of the 10 normal liver tissues and the para-carcinomal tissues of the 50 HCC patients,while the positive rates of nm-23-H1 and PTEN in liver cancerous tissues were 60%(30/50 cases)and 54%(27/50 cases)respectively,which were significantly lower than those of the para-carcinomal tissues(P 0.001,P 0.001,respectively).Furthermore,the down-regulations of nm23-H1 and PTEN proteins in HCC tissues were doesly related to the histological Edmondson grading,clinical stages,and intrahepatic metastasis,while no relation between their expressions and the gender,age,tumor size,liver capsule existing or AFP expression level was observed.Conclusions The reduced expressions of nm23-H1 and PTEN might contribute to tumor development and metastasis in HCC.Examination of protein expressions of nm23-H1 and PTEN in HCC may help to understand the malignance degree and the potential metastasis of the tumor." @default.
- W2359782022 created "2016-06-24" @default.
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- W2359782022 date "2010-01-01" @default.
- W2359782022 modified "2023-09-27" @default.
- W2359782022 title "Expressions of nm23-H1 and PTEN in hepatocellular carcinoma tissues and their clinicopathological significance" @default.
- W2359782022 hasPublicationYear "2010" @default.
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