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- W2359787716 abstract "Objective To investigate the transcription factor(TF)expression in human malignant astrocytomas.Method Human normal brain tissues and malignant astrocytoma s were studied.Sample1was a pool of3gradeⅢastrocytoma specimens,sample2was a pool of2grade IV glioblastoma specimens(GBM),sample3was a pool of4normal brain tissues.Reverse transcripted cDNA labeled with 33 P was hybridized with the array membrane that contained14000cDNA clones.Each gene was analyzed by comparing the image optical densities among the control sample and each of the tumor samples.A ratio2or1/2was thought to be a different expression.Result109TF genes were surveyed.GBM sample had a higher TFs expression ratio than gradeⅢastrocytoma sample(1.33±0.28vs.1.10±0.16,P0.001).Thirteen TFs abnormally expressed in2samples.GradeⅢsample had4up-regulated TFs and1down-regulated TF.GBM sample had6up-regulated TFs and5down-regulated TFs.TFⅡB was down regulated in both tumor samples(ratio=0.21in grad eⅢsample,=0.28in GBM sample).Two genes were up regulated in both tumor samples.They were HMGI-C(ratio=2.17and4.03respectively)and BTF262kD subunit(ratio=2.81and2.69respectively).Conclusion TFs are abnormally expressed in human malignant astrocytomas.TFⅡB,HMGI-C and BTF262kDa subunit are targets for further study." @default.
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- W2359787716 date "2001-01-01" @default.
- W2359787716 modified "2023-09-24" @default.
- W2359787716 title "Abnormal expression of transcription factors in malignant astrocytomas" @default.
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