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- W2359797778 abstract "Objective:The aim of this study was to investigate the expression of p63 in skin squamous cell carcinoma(SSCC) multistep carcinogenesis.Method:Sixty-eight cases of SSCC were studied using immunohistochemistry staining method for monoclone antibody p63.Results:In paracarcinoma normal or proliferative human epidermis ,in hair follicles, p63 protein was principally restricted to cell-basal cell, with high proliferative potential and absent from the cells that were keratinocyte undergoing terminal differentiation. In high differentiated tumors , p63 was confined to a ring of basal-like cells surrounding, In low differentiated tumors, most cells contained p63 and their distribution was chaotic with respect to centers of terinmal differentiation. Stronger p63 overexpressions could be seen in SSCC and skin intraepithelial neoplasm(SIN)Ⅲ degree than that in paracarcinoma normal or proliferation epithelial. A significant correlation between expression of the p63 and SSCC differentiated was observed.Conclusion: Overexpressions of p63 may be as SSCC and acquire a more aggressive and anaplasia phenotype , p63 appear to be a valuable for the proliferation and differentiation of SSCC." @default.
- W2359797778 created "2016-06-24" @default.
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- W2359797778 date "2001-01-01" @default.
- W2359797778 modified "2023-09-28" @default.
- W2359797778 title "THE EXPRESSION OF p63 IN SKIN SQUAMOUS CELL CARCINOMA" @default.
- W2359797778 hasPublicationYear "2001" @default.
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