Matches in SemOpenAlex for { <https://semopenalex.org/work/W2359798565> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2359798565 abstract "Objective To study the correlation between methylation of p16 gene in promotor region with the genesis and progress of colorectal cancer. Methods Methylation-specific PCR was used to detect methylation of p16 promotor region.Expression of p16 was examined by RT-PCR and immunohistochemistry techniques. Results In 58 cases of colorectal cancer, p16 expression was detected in 97%(56/58), 31%(18/58), and 7%(2/28) in paratumoral mucous membrana, primary cancer foci and hepatic metastasis respectively. p16 expression in primary foci and hepatic metastasis was lower than that in paratumoral mucous membrana (P0.01). Methylation of p16 promotor in primary foci and hepatic metastasis was found in 29/58(50%), and 21/28(75%)(P0.01).No methylation was found in paratumour mucous membrana. In 28 cases of hepatic metastasis, 23(82%) were found with p16 promotor methylation sequence in the venous blood, and 20(71%) in bile. Conclusion Methylation of p16 promotor leads to inhibition of p16 gene, genesis and metastasis of colorectal cancer." @default.
- W2359798565 created "2016-06-24" @default.
- W2359798565 creator A5061124623 @default.
- W2359798565 date "2003-01-01" @default.
- W2359798565 modified "2023-09-23" @default.
- W2359798565 title "Methylation of p16 gene in promotor region is related with the genesis and progress of colorectal cancer" @default.
- W2359798565 hasPublicationYear "2003" @default.
- W2359798565 type Work @default.
- W2359798565 sameAs 2359798565 @default.
- W2359798565 citedByCount "0" @default.
- W2359798565 crossrefType "journal-article" @default.
- W2359798565 hasAuthorship W2359798565A5061124623 @default.
- W2359798565 hasConcept C101762097 @default.
- W2359798565 hasConcept C104317684 @default.
- W2359798565 hasConcept C121608353 @default.
- W2359798565 hasConcept C126322002 @default.
- W2359798565 hasConcept C142724271 @default.
- W2359798565 hasConcept C150194340 @default.
- W2359798565 hasConcept C153911025 @default.
- W2359798565 hasConcept C190727270 @default.
- W2359798565 hasConcept C204232928 @default.
- W2359798565 hasConcept C2779013556 @default.
- W2359798565 hasConcept C33288867 @default.
- W2359798565 hasConcept C502942594 @default.
- W2359798565 hasConcept C526805850 @default.
- W2359798565 hasConcept C54355233 @default.
- W2359798565 hasConcept C71924100 @default.
- W2359798565 hasConcept C86803240 @default.
- W2359798565 hasConceptScore W2359798565C101762097 @default.
- W2359798565 hasConceptScore W2359798565C104317684 @default.
- W2359798565 hasConceptScore W2359798565C121608353 @default.
- W2359798565 hasConceptScore W2359798565C126322002 @default.
- W2359798565 hasConceptScore W2359798565C142724271 @default.
- W2359798565 hasConceptScore W2359798565C150194340 @default.
- W2359798565 hasConceptScore W2359798565C153911025 @default.
- W2359798565 hasConceptScore W2359798565C190727270 @default.
- W2359798565 hasConceptScore W2359798565C204232928 @default.
- W2359798565 hasConceptScore W2359798565C2779013556 @default.
- W2359798565 hasConceptScore W2359798565C33288867 @default.
- W2359798565 hasConceptScore W2359798565C502942594 @default.
- W2359798565 hasConceptScore W2359798565C526805850 @default.
- W2359798565 hasConceptScore W2359798565C54355233 @default.
- W2359798565 hasConceptScore W2359798565C71924100 @default.
- W2359798565 hasConceptScore W2359798565C86803240 @default.
- W2359798565 hasLocation W23597985651 @default.
- W2359798565 hasOpenAccess W2359798565 @default.
- W2359798565 hasPrimaryLocation W23597985651 @default.
- W2359798565 hasRelatedWork W1982435604 @default.
- W2359798565 hasRelatedWork W2017497141 @default.
- W2359798565 hasRelatedWork W2077538717 @default.
- W2359798565 hasRelatedWork W2127542859 @default.
- W2359798565 hasRelatedWork W2128130843 @default.
- W2359798565 hasRelatedWork W2188689241 @default.
- W2359798565 hasRelatedWork W2350271029 @default.
- W2359798565 hasRelatedWork W2350453690 @default.
- W2359798565 hasRelatedWork W2353963971 @default.
- W2359798565 hasRelatedWork W2358447883 @default.
- W2359798565 hasRelatedWork W2370059759 @default.
- W2359798565 hasRelatedWork W2381468359 @default.
- W2359798565 hasRelatedWork W2390983854 @default.
- W2359798565 hasRelatedWork W2606406923 @default.
- W2359798565 hasRelatedWork W3028955688 @default.
- W2359798565 hasRelatedWork W3030972903 @default.
- W2359798565 hasRelatedWork W3032277613 @default.
- W2359798565 hasRelatedWork W3032593970 @default.
- W2359798565 hasRelatedWork W3150744923 @default.
- W2359798565 hasRelatedWork W2059590399 @default.
- W2359798565 isParatext "false" @default.
- W2359798565 isRetracted "false" @default.
- W2359798565 magId "2359798565" @default.
- W2359798565 workType "article" @default.