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- W2359818604 abstract "Objective To explore the expression of Sp1,KLF4,and PTEN in pancreatic invasive ductal adenocarcinoma,and clarify their role in tumor angiogenesis of primary pancreatic ductal carcinoma.Methods Surgically resected specimens of 30 primary invasive ductal adenocarcinomas of pancreas were studied by immunohistochemical staining for SP1,KLF4,and PTEN.The MVD was evaluated by CD31 immunostaining.Results Twenty(67%) of the cases showed high SP1 nuclear expression,20(67%) of the cases had a high KLF4 cytoplasm reaction,and only 7(23%) cases were PTEN cytoplasm intensively positive.Positive correlation was found between the SP1 expression and MVD(r=0.765,P0.001) .Negative correlation was detected between the PTEN expression and MVD(r=-0.465,P0.05) .KLF4 expression did not show any relationship with MVD.SP1 high expression was associated with a significant lower PTEN and KLF4 expression in tumor tissue(P0.001,P0.05) .Conclusion Our findings suggest that SP1 and PTEN are involved in the tumor angiogenesis in primary pancreatic ductal adenocarcinomas.PTEN and KLF4 gene might be a tumor suppressor gene for pancreatic carcinomas." @default.
- W2359818604 created "2016-06-24" @default.
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- W2359818604 date "2007-01-01" @default.
- W2359818604 modified "2023-09-26" @default.
- W2359818604 title "Expression of Sp1,PTEN and KLF4 in primary pancreatic invasive ductal adenocarcinoma:Correlation with microvessel density" @default.
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