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- W2359831659 abstract "Objective To study effects of fluoride on the endocrine glands and secretion of hormones. Method By using case-control study method, hormones contents of serum from the pituitarys and thyoids and gonads were determined in the mice and the crowd in high-fluoride area to observe the relations between high-fluoride and concerned endocrine hormones. Result In pace with increase of contaminate-fluoride dose in the mather's body, concentration of serum thyroid-stimulating hormone(TSH), thyroxine(T 4), estradiol(E 2) and progesterone(P) were gradually reduced in the test mice, serum TSH, T 4 and E 2 of high-dose group(500mg/L NaF) were significantly lower than that of control group(P0.05). Serum testosterone(T) of the male crowd in high-fluoride area was significantly lower than that of the normal crowd(P0.05), and serum luteinizing hormone(LH), folliele-stimulating hormone (FSH) were significantly higher than that of the normal crowd (P0.05);Serum FSH, LH, E 2, P contents of the female crowd in high-fluoride area were lower than that of the normal crowd, and serum LH, E 2 of the female corwd in the high-fluoride area were significantly lower than that of the normal crowd(P0.05). Conclusion High-fluoride state may result in damage of pituitarys,thyroids and gonads and affect secretion of hormones; Effects of fluoride on endocrine function of organism may pass on filial generation by reproductive course,and cause injure of endocrine function in filial generation." @default.
- W2359831659 created "2016-06-24" @default.
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- W2359831659 date "2004-01-01" @default.
- W2359831659 modified "2023-09-23" @default.
- W2359831659 title "Effects of Fluoride on Secretion of Hormone" @default.
- W2359831659 hasPublicationYear "2004" @default.
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