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- W2359835561 abstract "Objectives To investigate the involvement of VEGF in the occurrence and development of non small cell carcinoma of lung by examination of the expression of VEGF and CD34 between NSCLC, inflammatory pseudotumor of lung and normal lung tissue with immunohistochemical staining, to study the relationship between VEGF expression and angiogenesis in NSCLC.Methods Immunohistochemical staining was performed by anti VEGF polyclonal antibody and anti CD34 monoclonal antibodies, and the degree of antibody reactivity with individual tissue sections was considered to be positive if unequivocal brown yellow staining of membrane or cytoplasm was seen in tumor cells. Results The total positive rate of 81 patients is 72.84%,VEGF was mainly distributed in cytoplasm and membrane of tumor cell,some tumors demonstrated positive staining in the basal lamina or extracellular stroma ,so did some normal tissue.Positive cell showed diffuse or local diffusion in SQCC and surrounded around adeno alveola in ADC.It was found that there was a close relationship between MVD and VEGF expression in NSCLC and MVD increased with the higher expression of VEGF ( P 0.001 ). Conclusion Expression of VEGF is closely related to the occurrence and development of NSCLC and plays an important role in neo angiogenesis, it may act as a diagnostics marker for clinical biological characteristic in NSCLC." @default.
- W2359835561 created "2016-06-24" @default.
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- W2359835561 date "2002-01-01" @default.
- W2359835561 modified "2023-09-25" @default.
- W2359835561 title "Clinical significance of VEGF expression and its correlation with angiogenesis in non-small-cell carcinoma of lung" @default.
- W2359835561 hasPublicationYear "2002" @default.
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