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- W2359843549 abstract "Objective To study the effects of curcumin on the Lymphatic Metastasis in Human Uterine Cervical Cancer animal model. Methods: The CAM model of lymphatic metastasis in cervical cancer was established to study the effects of curcumin on IGF-1 related Lymphatic Metastasis of xenotransplanted tumor and the lymphatic microvessel density( LMVD). Moreover,lymphatic vessel area( LVA) was measured and analyzed in this model. Results ①We successfully established the chick chorioallantoic membrane( CAM) model of lymphagenesis in cervical cancer and found that 107/ L was the optimal concentrations of implantation of cancer cells in vitro. ② The microlymphatics could be observed in intratumor in the CAM( Immune histochemistry staining). ③LMVD of the control,IGF-1,Cur and IGF-1 + Cur groups were 21. 28 ± 10. 13、28. 58 ± 12. 26、16. 23 ± 8. 76 and 18. 23 ± 9. 36 /4HP respectively. Similarly,LVA were 2. 91 ± 1. 16、3. 42 ± 1. 25、2. 00 ± 1. 51 and 2. 72 ± 1. 21% in the control,IGF-1, Cur and IGF-1 + Cur groups( p 0. 05). Conclusion The expression of VEGF-C was up-regulated by IGF-1 in cervical cancer,which could be inhibited by addition of curcumin. The present research may imply in clinical application with Cur to inhibit the lymphagenesis in cervical cancer in future." @default.
- W2359843549 created "2016-06-24" @default.
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- W2359843549 date "2013-01-01" @default.
- W2359843549 modified "2023-09-25" @default.
- W2359843549 title "Effects of Curcumin on Lymphatic Metastasis in Human Uterine Cervical Cancer Animal Model" @default.
- W2359843549 hasPublicationYear "2013" @default.
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