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- W2359847178 abstract "Objective:To investigate the level and clinical significance of plasma Adiponectin and Apelin in coronary heart disease(CHD) patients accompanied with abnormal glucose metabolism.Method: 87 patients with coronary heart disease,confirmed by coronary artery angiography,were enrolled from Xiangya hospital.The according Gensini scores were figured out.Among them,28 out of 87 CHD patients were diagnosed as imparied glucose tolerence and diabetic mellitus(CHD+IGT/CHD+DM group).And the other 31 patients were enrolled in CHD group.Meanwhile,31 healthy volunteers were enrolled in NC group.All subjects received detection of height,weight,waist circumstance(WC),BMI,blood lipid,glucose,insulin,HbA1c,hs-CRP,also Apelin and Adiponectin(ELISA).The degree of insulin resistance was assessed by the homeostasis model assessment insulin resistance index(HOMA-IR).Result:Compared with group NC,the levels of Adiponectin and Apelin in the groups of CHD+IGT,CHD+DM and CHD decreased significantly(all P0.05).The level of Adiponectin was lower in group CHD+DM than in group CHD+IGT and CHD(P0.05),while Apelin were lower in group CHD than in group CHD+DM and NC(P0.05).Adiponectin was positively correlated with HDL-C(P0.01) and negatively correlated with hs-CRP and uric acid(P0.05).In patients with coronary heart disease,Apelin was positively correlated with 2h post-prandial glucose(PPG),after blood pressure and age were controlled,it was positively correlated with BMI、PPG and HOMA(all P0.05).Conclusion:Plasma Adiponectin decreased most significantly in group of CHD patients accompanied with DM,while Apelin was lower than the normal people and higher than the CHD(had no difference with CHD+IGT),indicating that Apelin may be involved in the happening of DM,but not during the period of IGT.Since Apelin was usually affected by glucose metabolism,it couldn't exactlyevaluate and reflect the severity of disease in CHD patients accompanied with abnormal glucose metabolism like Adiponectin." @default.
- W2359847178 created "2016-06-24" @default.
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- W2359847178 date "2011-01-01" @default.
- W2359847178 modified "2023-09-25" @default.
- W2359847178 title "Clinical significance of plasma Adiponectin and Apelin in coronary heart disease patients accompanied with abnormal glucose metabolism" @default.
- W2359847178 hasPublicationYear "2011" @default.
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