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- W2359852078 abstract "[Objective] To study Aurora-A gene expression status of lung cancer and its influence on genesis of lung cancer in vivo.[Methods] The levels of Aurora-A mRNA and protein of lung cancer samples were detected by RT PCR,Western Blot or/and immunohistochemistry respectively.[Results] In 30 cases of lung cancer patients,the over-expressions of Aurora-A mRNA were observed in 19 cases(63%) compared with neighboring tissues(P0.05).Western blot was adopted to assess the status of Aurora-A protein expressed in tumor in vivo from 20 patients.The over-expressioof Aurora-A protein n was detected in 13 cases(65%) compared with their neighboring tissue(P0.05).Correspondingly,over expression were also found in 32 cases(66.67%)of 48 cases dectected by immunohistochemistry.No significant correlation existing between over expression of Aurora-A mRNA and sex,smoking history and pathological characteristics was found.On the contrary,correlation was observed between over expression level of Aurora-A protein and metastases in 48 squamous lung cancer patients.[Conclusion] The Aurora-A is highly expressed in lung cancer tissue than in neighboring tissue,suggesting the over expressed Aurora-A be one of oncogenetic factors of lung cancer." @default.
- W2359852078 created "2016-06-24" @default.
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- W2359852078 date "2007-01-01" @default.
- W2359852078 modified "2023-09-28" @default.
- W2359852078 title "Expression of aurora-A kinase in different human lung cancer" @default.
- W2359852078 hasPublicationYear "2007" @default.
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