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- W2359858368 abstract "Objective To understand the sero-prevalence,HBV serum marker models and related risk factors of occult HBV infected donors in Xi'an and to reduce the risks in transfusion-transmitted HBV infections.Methods 263 501 volunteer blood donation samples were collected from June 2012 to December 2013.All samples were tested by ELISA first,followed by NAT in the qualified samples.The samples with HBsA g(-) DNA(+) were further tested for the five serological markers and were analyzed on their serological pattern.Besides,multivariable logistic regression analysis was conducted on the information originated from volunteer blood donors.Results Of all 276 341 donors negative for HBsA g,171 donors were positive for HBV DNA.Among these 171 donors,157 demonstrated either the presence of anti-HBs(+) or anti-HBc(+).The rate of occult HBV infection in blood donors in Xi'an was then determined to be 0.06%.Multivariable logistic regression analysis showed that occult HBV infection is associated with age and whether the donor is a repeated blood donor.Donors over forty years old and donating blood for the first time had a higher percentage of occult HBV infections.Conclusion Donors negative for HBsA g but positive for other HBV markers cannot rule out HBV infection.Nucleic acid testing is especially useful for enhancing the detection rate of occult HBV infection in blood donor units.Occult HBV infection in blood donors in Xi'an was associated with age and repeated donor status of blood donors." @default.
- W2359858368 created "2016-06-24" @default.
- W2359858368 creator A5005988865 @default.
- W2359858368 date "2015-01-01" @default.
- W2359858368 modified "2023-09-23" @default.
- W2359858368 title "The sero-prevalence and multivariable analysis on risk factors of blood donors with occult HBV infection in Xian" @default.
- W2359858368 hasPublicationYear "2015" @default.
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