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- W2359859051 abstract "Objective To investigate association of polymorphisms of endothelial nitric oxide synthase(eNOS) gene with type 2 diabetes mellitus(2DM) and diabetic nephropathy. Methods The eNOS genotypes(4A/B 27-bp tanden repeat polymorphism at 4 intron) were determined with polymerase chain reaction analysis in 399 2DM patients and 113 normal glucose tolerance(NGT) control subjects in Hefei region. According to the urine albumin excretion rate, 302 of 2DM subjects were divided into four groups, which consisted of normal excretion rate group(114 cases), micro-urine albumin excretion rate group(140), clinical diabetic nephropathy group(35) and end-stage renal disease group(13). The genotypes frequency and allele frequency were compared among these groups. Results There were no statistically significant differences of genotypes and allele frequency in eNOS gene 4A/B polymorphism between 2DM and NGT group. There were significant differences in the frequencies of A allele(6.6%, 15%, 15.7% and 11.5%) and B/B?穴88.6%,71.4%, 74.3% and 76.9%), A/B(9.6%,27.1%, 20% and 23.1%)genotypes among the four 2DM groups(P=0.009, P=0.006, P=0.002). A allele frequency increased with the exacerbation of diabetic nephropathy(P=0.01). Conclusions These results implied that 4A/B polymorphism of eNOS gene may be not associated with the occurrence of type 2 diabetes mellitus, but it, especially A allele, may be related to the development of diabetic nephropathy." @default.
- W2359859051 created "2016-06-24" @default.
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- W2359859051 date "2004-01-01" @default.
- W2359859051 modified "2023-09-24" @default.
- W2359859051 title "Study on the Correlation of the Polymorphisms of Endothelial Nitric Oxide Synthase Gene with type 2 Diabetes Mellitus and Diabetic Nephropathy." @default.
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