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- W2359859105 abstract "Objective To examine the fasting serum total homocysteine (tHcy) levels in aged subjects with metabolic syndrome (MS) or MS accompanied by coronary atherosclerotic heart disease (MS+CHD), and to investigate the relationship between tHcy levels and features of MS.Methods Fasting serum tHcy levels were measured in 34 MS patients, 30 MS+CHD patients and 16 healthy controls by means of immunochemiluminometric assay method. The information on conventional clinical features of MS was collected.Results (1) Univariate analysis revealed significant difference in tHcy concentrations between controls [(10.9±3.8) μmol/L], and subjects with MS [(14.3±4.2) μmol/L], or subjects with MS+CHD [(19.2±2.9) μmol/L];(2) Correlation analysis results suggested that the serum tHcy concentration was related to insulin sensitivity index (ISI) (r=-0.221, P0.05), or to components of the MS, including body mass index (BMI) (r=0.125, P0.05), fasting blood sugar (FBS) (r=0.218, P0.05), or HbA1c (r=0.312 , P0.05);(3)Logistic regression analysis indicated a statistically significant relationship between tHcy concentration and ISI (r 2=0.23, P0.05)、HbA1c(r 2=0.21, P0.05) or TG (r 2=0.15, P 0.05 ).Conclusion These findings strengthen the possibility that disturbed homocysteine metabolism is related to the decrease in insulin sensitivity, and may contribute to development to coronary atherosclerotic heart disease from metabolic syndrome." @default.
- W2359859105 created "2016-06-24" @default.
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- W2359859105 date "2004-01-01" @default.
- W2359859105 modified "2023-09-25" @default.
- W2359859105 title "Relationship between insulin sensitivity and serum total homocysteine in aged patients with metabolic syndrome accompanied by coronary atherosclerotic heart disease" @default.
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