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- W2359864618 abstract "Objective To observe the therapeutic effect of Huachansu combined with chemotherapy on mice with orthotopic transplantation hepatocellular carcinoma ( H22 ) . Methods Forty BALB/C mice were randomly divided into control group,fluorouracil group,Huachansu( HCS) group and fluorouracil plus HCS group. After the models of orthotopic transplantation hepatocellular carcinoma ( H22) were established in the mice. The normal saline( 0. 2ml) ,fluorouracil ( 30 mg/kg) ,HCS u( 5ml/kg) ,fluorouracil ( 30mg/kg) plus HCS ( 5ml/kg) were injected intraperitoneally,respectively in the mice of four groups. groups. After the drugs had been administered completely for there days,all the mice were sacrificed,the tumors and the thymus were weighed. The inhibition tumor rates and thymus index were calculated and compared among the four groups. The cell cycle and cell apoptosis were detected by flow cytometry. The content of TNF-α in serum was examined by desmoglein enzyme linked immunosorbent assay ( ELISA) . Results The inhibition effect of tumor growth in fluorouracil group and HCS group was obvious. The inhibition effect was more obvious in fluorouracil plus HCS group. HCS was able to increase the weight of thymus and the thymus index. As compared with control group,the percentage of S phase of cell cycle was increased in HCS group and the percentage of G2 /M phase was increased in fluorouracil group. Both of the percentages were increased in fluorouracil plus HCS group. Conclusion There exists synergistic inhibitory effect between HCS and fluorouracil on hepatocellular carcinoma. The toxicity of fluorouracil is decreased by HCS." @default.
- W2359864618 created "2016-06-24" @default.
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- W2359864618 date "2010-01-01" @default.
- W2359864618 modified "2023-09-23" @default.
- W2359864618 title "Therapeutic effect of Huachansu combined with chemotherapy on mice with orthotopic transplantation hepatocellular carcinoma" @default.
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