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- W2359890335 abstract "Objective To investigate the effect of Tongmai oral liquid on the early diabetic nephropathy. Methods Diabetic nephropathy rats were induced by excision of the right kidney and a single intraperitoneal injection of streptozotocin (STZ). Forty male Wistar rats were divided randomly into 3 groups:Tongmai group, nephrotic model group, and normal group. At the end of the 8th week, the rats general states and some parameters such as kidney hypertrophy index, 24 h urine volume, blood glucose, 24 h urinary microalbumin (24 h UMA), renal function [serum creatinine (Cr), blood urea nitrogen (BUN)], serum lipid, and the change of nephritic pathologic lesion were measured. Result Compared with the model group, general states in Tongmai group were improved, there was a considerable increase on body weight (P 0.01). Compared with the model group, there was a significantly decrease (P 0.01) on the kidney hypertrophy index, blood glucose, BUN and Cr in Tongmai group. The pathologic lesion in kidney morphology were also ameliorated obviously. But there were no remarkable differences in the 24 h urine volume and serum lipid index. Conclusion Tongmai oral liquid can prevent and cure the Ⅱ period diabetic nephropathy by controlling blood glucose and improving renal hemodynamics." @default.
- W2359890335 created "2016-06-24" @default.
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- W2359890335 date "2009-01-01" @default.
- W2359890335 modified "2023-09-27" @default.
- W2359890335 title "Pharmacodynamic Research of Tongmai Oral Liquid on Preventing and CuringIIPeriod Diabetic Nephropathy" @default.
- W2359890335 hasPublicationYear "2009" @default.
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