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- W2359894503 abstract "Background and Purpose:Pancreatic cancer is malignant tumor of the digestive tract with poor prognosis and is not sensitive to conventional chemotherapy.This study investigates the safety and feasibility of regional arterial ligation followed by intra-arterial perfusion chemotherapy in 14 pigs divided into groups A,B and C.Methods:14 pigs were divided into 3 groups.Group A(n=5) underwent gastroduodenal artery ligation and catheterization through the right gastroepiploic artery.Group B(n=5) underwent splenic artery ligation and catheterization.Group C(n=4) underwent left periotic vein puncture.5-FU(20mg/kg) was perfused into these catheters in 60 min.Blood samples and pancreatic tissue were obtained for the purposes of the determination of drug concentration and pathological diagnosis.Results:At 80 min and 100 min the drug concentration in portal vein of group A and group B were higher than those of group C(P0.05,P0.01 respectively).The concentration of 5-FU in jugular vein of group A and B at 20 min,40 min and 60 min were much lower than those of group C.The concentrations of 5-FU in pancreatic tissue of group A and B at 40 min and 80 min were much higher than those of group C(P0.01).There were no significant differences between the blood sugar,amylase and insulin levels before,2 hours and 24 hours after perfusion in each group.After 5-FU treatment,most of the samples were pathologically normal in pancreatic tissue by HE stain.A few of them showed variable degrees of edema in pancreatic tissue.There was no obvious necrosis found in the samples.Pancreatic islets were normal in most animals by ABC immunohistological stain,while there were lymphcytes in pancreatic islets in a few of them and β cells of pancreatic islets were slightly damaged in rare cases.Conclusions:Compared with systemic chemotherapy,regional perfusion of pancreas with 5-FU after gastroduodenal artery or splenic artery ligation significantly increased the concentration of 5-FU in pancreatic tissue and decreased the peripheral drug concentration and had no influences on blood sugar, amylase,insulin levels,and had no severe damage to pancreatic histologic structure and pancreatic islets β-cells." @default.
- W2359894503 created "2016-06-24" @default.
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- W2359894503 date "2006-01-01" @default.
- W2359894503 modified "2023-09-27" @default.
- W2359894503 title "Animal study on the feasibility of regional gastroduodenal artery or splenic artery ligation followed by regional intraarterial perfusion of pancreas with 5-FU" @default.
- W2359894503 hasPublicationYear "2006" @default.
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