Matches in SemOpenAlex for { <https://semopenalex.org/work/W2359897185> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2359897185 abstract "Objective: To investigate the mechanism underlying the role of C-reactive protein(CRP) in endothelial cells and the effect of statin on inflammatory factors such as tumor necrosis factorα(TNF-α) and interleukin-6(IL-6) stimulated by CRP.Methods: The response of vascular endothelial cells (HUVECs) to CRP was investigated and compared with the response to lipopolysaccharide(LPS).Further we observed whether the redox-responsive transcription factor NF-kappaB(NF-κB) involved in this response of HUVECs by CRP.At last the effects of pravastatin were observed.Results: The present study showed that CRP increased the release of TNF-α and IL-6 as well as LPS did in HUVECs.In HUVECs induction of TNF-α and IL-6 was already presented at 5 mg/L and reached a maximum at 100 mg/L of CRP,at which point a substantial increase in expression of TNF-α and IL-6 were evident.The CRP effect was time-dependent(0-48 h) and dose-dependent(0-100 mg/L).CRP induced activation of NF-κB in HUVECs and the activation were inhibited by pravastatin.Conclusion: CRP causes NF-κB activation of HUVECs which could lead to the induction of TNF-α and IL-6 as well as LPS does.This effect can be inhibited by pravastatin.CRP may play a role in atherogenesis by activating endothelial cells at least in part through NF-κB and statins inhibit this response,which may provide an insight into the mechanisms of anti-inflammatory or anti-atherosclerotic actions of statins." @default.
- W2359897185 created "2016-06-24" @default.
- W2359897185 creator A5078648892 @default.
- W2359897185 date "2008-01-01" @default.
- W2359897185 modified "2023-09-25" @default.
- W2359897185 title "Inhibition of Pravastatin on the Release of TNF-Alpha and IL-6 by HUVECs Stimulated by C-Reactive Protein" @default.
- W2359897185 hasPublicationYear "2008" @default.
- W2359897185 type Work @default.
- W2359897185 sameAs 2359897185 @default.
- W2359897185 citedByCount "0" @default.
- W2359897185 crossrefType "journal-article" @default.
- W2359897185 hasAuthorship W2359897185A5078648892 @default.
- W2359897185 hasConcept C11988809 @default.
- W2359897185 hasConcept C126322002 @default.
- W2359897185 hasConcept C134018914 @default.
- W2359897185 hasConcept C17991360 @default.
- W2359897185 hasConcept C185592680 @default.
- W2359897185 hasConcept C203014093 @default.
- W2359897185 hasConcept C2776839432 @default.
- W2359897185 hasConcept C2776914184 @default.
- W2359897185 hasConcept C2777730290 @default.
- W2359897185 hasConcept C2778163477 @default.
- W2359897185 hasConcept C2778690821 @default.
- W2359897185 hasConcept C2778754761 @default.
- W2359897185 hasConcept C2779519902 @default.
- W2359897185 hasConcept C2781195455 @default.
- W2359897185 hasConcept C71924100 @default.
- W2359897185 hasConcept C74172505 @default.
- W2359897185 hasConcept C98274493 @default.
- W2359897185 hasConceptScore W2359897185C11988809 @default.
- W2359897185 hasConceptScore W2359897185C126322002 @default.
- W2359897185 hasConceptScore W2359897185C134018914 @default.
- W2359897185 hasConceptScore W2359897185C17991360 @default.
- W2359897185 hasConceptScore W2359897185C185592680 @default.
- W2359897185 hasConceptScore W2359897185C203014093 @default.
- W2359897185 hasConceptScore W2359897185C2776839432 @default.
- W2359897185 hasConceptScore W2359897185C2776914184 @default.
- W2359897185 hasConceptScore W2359897185C2777730290 @default.
- W2359897185 hasConceptScore W2359897185C2778163477 @default.
- W2359897185 hasConceptScore W2359897185C2778690821 @default.
- W2359897185 hasConceptScore W2359897185C2778754761 @default.
- W2359897185 hasConceptScore W2359897185C2779519902 @default.
- W2359897185 hasConceptScore W2359897185C2781195455 @default.
- W2359897185 hasConceptScore W2359897185C71924100 @default.
- W2359897185 hasConceptScore W2359897185C74172505 @default.
- W2359897185 hasConceptScore W2359897185C98274493 @default.
- W2359897185 hasLocation W23598971851 @default.
- W2359897185 hasOpenAccess W2359897185 @default.
- W2359897185 hasPrimaryLocation W23598971851 @default.
- W2359897185 hasRelatedWork W181071056 @default.
- W2359897185 hasRelatedWork W1974210110 @default.
- W2359897185 hasRelatedWork W1985170278 @default.
- W2359897185 hasRelatedWork W2009826185 @default.
- W2359897185 hasRelatedWork W2056622235 @default.
- W2359897185 hasRelatedWork W2056938401 @default.
- W2359897185 hasRelatedWork W2060640331 @default.
- W2359897185 hasRelatedWork W2067885422 @default.
- W2359897185 hasRelatedWork W2097796010 @default.
- W2359897185 hasRelatedWork W2117992248 @default.
- W2359897185 hasRelatedWork W2122906271 @default.
- W2359897185 hasRelatedWork W2147371894 @default.
- W2359897185 hasRelatedWork W2191680141 @default.
- W2359897185 hasRelatedWork W2370223615 @default.
- W2359897185 hasRelatedWork W2561313848 @default.
- W2359897185 hasRelatedWork W2588048543 @default.
- W2359897185 hasRelatedWork W2886831700 @default.
- W2359897185 hasRelatedWork W2887133289 @default.
- W2359897185 hasRelatedWork W2131537873 @default.
- W2359897185 hasRelatedWork W3140658965 @default.
- W2359897185 isParatext "false" @default.
- W2359897185 isRetracted "false" @default.
- W2359897185 magId "2359897185" @default.
- W2359897185 workType "article" @default.