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- W2359897637 abstract "OBJECTIVE To study the mechanism relative to therapeutic effects of matrine on adenine-induced renal interstitial fibrosis in rats. METHODS Sixty male Wistar rats were selected and randomly divided into 3 groups. ① Eight rats were designed in normal control group; ②Tweenty-eight rats were designed in the pathological group; ③ Twenty four rats were designed in the matrine group. Each rat in pathological group and matnne group was feed with adenine(250 mg·kg-1 ·d-1) orally for 21 d. After the treatment with adenine for one week, each rat in matrine group ( 20 mg · kg-1 ·d-1)in vehicle(1 mL of 0.9% sodium chloride) was administered by intraperitoneal injection. Serum urea nitrogen, creatinine. IL-6 and to examine pathology of kidney in pathological group. Matrine group normal and control group were determined after two weeks,three weeks and for weeks, respectively. Serum IL-6 was measured by radioimmunoassay.TGF-β1 expression in kidney was determined by immunohistochemical staining and semiquantitative analysis. Tubulointerstitial injury was evaluated by HE staining for semi-quantitative analysis. RESULTS In matnne treated group, the renal function was superior to that in pathological group ( P 0.05), serum IL-6 and renal TGF-β1 express level were obviously lower than that in pathological group ( P 0.05) ,but all these indexes were higher than that in normal control group ( P 0.01 ) .In matrine group, the index of tubulointerstitial injury was lower than that in pathologal group ( P 0.05). CONCLUSION These data suggest that matnne mhibites the renal tubulointerstial fibrosis in adenine-induced rats model, which is involved in suppressing serum level of IL-6 and the expression of TGF-β1 in the tubulointerstitium." @default.
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- W2359897637 title "Effects of matrine on adenine-induced chronic tubulointerstitial fibrosis in rats" @default.
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