Matches in SemOpenAlex for { <https://semopenalex.org/work/W2359901265> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2359901265 abstract "Introduction Management of bipolar disorder is limited by absence of laboratory test. While alterations related to multiple biological pathways have been found in bipolar disorder, findings have not translated into clinically applicable biomarkers. We previously found promise for a combined gene expression biomarker. The combination of gene expression and proteomic biomarkers could have potential as a meaningful clinical test. Objectives To identify a composite biomarker based on multiple potential peripheral biomarkers related to neuroplasticity, inflammation and oxidative stress, both on a proteomic and gene expression level. Aims To test the ability of a composite biomarker to discriminate between bipolar disorder patients and healthy control subjects and between affective states in bipolar disorder patients. Methods mRNA expression of a set of 19 candidate genes and protein levels of immune markers and neurotrophic factors were measured in peripheral blood mononuclear cells and combined with urinary levels of oxidized nucleosides of 37 rapid cycling bipolar disorder patients in different affective states (depression, mania and euthymia) during a 6–12-month period and in 40 age- and gender-matched healthy control subjects. A composite measure was constructed in the first half of the sample and independently validated in the second half of the sample. The composite measure was evaluated using ROC curves and by calculating sensitivity and specificity. Results Statistical analysis is ongoing. Results will be presented at the congress. Conclusions A peripheral composite biomarker based on multiple biological pathways on both proteomic and gene expression levels may have potential as a clinically applicable biomarker. Disclosure of interest The authors have not supplied their declaration of competing interest." @default.
- W2359901265 created "2016-06-24" @default.
- W2359901265 creator A5074715169 @default.
- W2359901265 creator A5086140343 @default.
- W2359901265 creator A5089171557 @default.
- W2359901265 date "2016-03-01" @default.
- W2359901265 modified "2023-09-27" @default.
- W2359901265 title "A peripheral composite proteomic and gene expression biomarker related to diagnosis and affective state in rapid cycling bipolar disorder" @default.
- W2359901265 doi "https://doi.org/10.1016/j.eurpsy.2016.01.156" @default.
- W2359901265 hasPublicationYear "2016" @default.
- W2359901265 type Work @default.
- W2359901265 sameAs 2359901265 @default.
- W2359901265 citedByCount "0" @default.
- W2359901265 crossrefType "journal-article" @default.
- W2359901265 hasAuthorship W2359901265A5074715169 @default.
- W2359901265 hasAuthorship W2359901265A5086140343 @default.
- W2359901265 hasAuthorship W2359901265A5089171557 @default.
- W2359901265 hasConcept C104317684 @default.
- W2359901265 hasConcept C126322002 @default.
- W2359901265 hasConcept C143998085 @default.
- W2359901265 hasConcept C150194340 @default.
- W2359901265 hasConcept C15744967 @default.
- W2359901265 hasConcept C2776174506 @default.
- W2359901265 hasConcept C2776809841 @default.
- W2359901265 hasConcept C2777089681 @default.
- W2359901265 hasConcept C2778541603 @default.
- W2359901265 hasConcept C2781197716 @default.
- W2359901265 hasConcept C54355233 @default.
- W2359901265 hasConcept C71924100 @default.
- W2359901265 hasConcept C86803240 @default.
- W2359901265 hasConceptScore W2359901265C104317684 @default.
- W2359901265 hasConceptScore W2359901265C126322002 @default.
- W2359901265 hasConceptScore W2359901265C143998085 @default.
- W2359901265 hasConceptScore W2359901265C150194340 @default.
- W2359901265 hasConceptScore W2359901265C15744967 @default.
- W2359901265 hasConceptScore W2359901265C2776174506 @default.
- W2359901265 hasConceptScore W2359901265C2776809841 @default.
- W2359901265 hasConceptScore W2359901265C2777089681 @default.
- W2359901265 hasConceptScore W2359901265C2778541603 @default.
- W2359901265 hasConceptScore W2359901265C2781197716 @default.
- W2359901265 hasConceptScore W2359901265C54355233 @default.
- W2359901265 hasConceptScore W2359901265C71924100 @default.
- W2359901265 hasConceptScore W2359901265C86803240 @default.
- W2359901265 hasLocation W23599012651 @default.
- W2359901265 hasOpenAccess W2359901265 @default.
- W2359901265 hasPrimaryLocation W23599012651 @default.
- W2359901265 hasRelatedWork W1938596530 @default.
- W2359901265 hasRelatedWork W1970988620 @default.
- W2359901265 hasRelatedWork W1973063716 @default.
- W2359901265 hasRelatedWork W1974040610 @default.
- W2359901265 hasRelatedWork W1996758446 @default.
- W2359901265 hasRelatedWork W2056711658 @default.
- W2359901265 hasRelatedWork W2064404868 @default.
- W2359901265 hasRelatedWork W2065628230 @default.
- W2359901265 hasRelatedWork W2065980876 @default.
- W2359901265 hasRelatedWork W2072475228 @default.
- W2359901265 hasRelatedWork W2074918990 @default.
- W2359901265 hasRelatedWork W2336476615 @default.
- W2359901265 hasRelatedWork W2466804257 @default.
- W2359901265 hasRelatedWork W2556274377 @default.
- W2359901265 hasRelatedWork W2745447190 @default.
- W2359901265 hasRelatedWork W2767482553 @default.
- W2359901265 hasRelatedWork W3022312722 @default.
- W2359901265 hasRelatedWork W3048664302 @default.
- W2359901265 hasRelatedWork W3165751361 @default.
- W2359901265 hasRelatedWork W3197501119 @default.
- W2359901265 isParatext "false" @default.
- W2359901265 isRetracted "false" @default.
- W2359901265 magId "2359901265" @default.
- W2359901265 workType "article" @default.