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- W2359908432 abstract "Objective To establish a HPLC-MS/MS method in order to determine vandetanib in human plasma.Methods The Intersil ODS-3 RP18 column was used as analytical column with a mobile phase consisted a mixture of ammonium acetate(0.02 mol·L-1,pH=3) and acetonitrile(70∶30),the flow rate was 200 mL·min-1.The plasma sample was wiped off protein with methyl tert-butyl ether(MTBE).Quantification was performed with positive ion MS/MS employing a TurboIonSpray interface.Results The linear range was 5-1000 ng·mL-1.The absolute recovery of 15,500,800 ng·mL-1was 95.4%,102.4%,97.2%,respectively.The intra-batch and inter-batch deviations were in high precision(RSD10%).Conclusion The method is proved to be stable,sensitive,accurate,rapid,specific and suitable for the clinical pharmacokinetics study." @default.
- W2359908432 created "2016-06-24" @default.
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- W2359908432 date "2013-01-01" @default.
- W2359908432 modified "2023-09-24" @default.
- W2359908432 title "Determination of vandetanib in Chinese cancer patients by LC-MS/MS" @default.
- W2359908432 hasPublicationYear "2013" @default.
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