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- W2359913422 abstract "AIM To evaluate the feasibility and anti-tumor effect of combined therapy of O-chloroacetylcarbamoyl fumagillol(TNP-470) and 5-fluorouracil(5-FU) in nu/nu mice model of human gastric cancer. METHODS Thirty two BALB/c nu/nu mice, which had been inoculated human gastric adenocarcinoma cell line subcutaneously, were divided into four groups and received treatment subcutaneously every other day. ① TNP-470 50 mg·kg -1, ② 5-FU 30 mg·kg -1, ③ TNP-470 50 mg·kg -1+5-FU 30 mg·kg -1, ④ TNP-470 vehicle(3% ethanol plus 5% gum arabic in saline). The volume of transplanted tumors were measured every week, after 4 weeks, the nude mice were sacrificed and the tumors were immediately removed for testing the VEGF 165 mRNA by RT-PCR and microvessel density(MVD) by streptavidin-alkaline phosphatase staining method. RESULTS The tumor suppression rates at 4 weeks after inoculation were 98.8%, 69.7% and 86.7%, respectively, in the three treated groups, otherwise the tumor volume in combinated group was more smaller than in other two groups at 3 weeks, combination therapy of TNP-470 with 5-FU showed more marked inhibition on the growth of gastric cancer. But the expression of VEGF 165 mRNA among the four groups had no significant difference (P0.05). MVD in the four groups were 3.8±0.6, 8.8±4.8, 4.8±0.4, 8.8±1.3, respectively, the MVD in TNP-470 group and combined one were lower than the other two groups (P0.05), indicating that TNP-470 could inhibit the neovascularization in gastric cancer, whereas 5-FU could not. CONCLUSION Combination therapy of TNP-470 with 5-FU shows more remarkable inhibition on the growth of transplanted gastric cancer in nude mice than single therapy of TNP-470 or 5-FU." @default.
- W2359913422 created "2016-06-24" @default.
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- W2359913422 date "2003-01-01" @default.
- W2359913422 modified "2023-09-25" @default.
- W2359913422 title "O-chloroacetylcarbamoyl fumagillol combined with 5-fluorouracil in suppression of the growth of gastric cancer" @default.
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