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- W2359920596 abstract "Objective To investigate the correlation between hypoxia-inducible factor-1α(HIF-1α) gene polymorphism and the genetic susceptibility of hepatopulmonary syndrome(HPS).Methods Two hundred and forty-five patients with hepatic cirrhosis hospitalized in our institution from May 2006 to Sep.2009 were divided into group HPS(n=63) and group non-HPS(n=182) according to whether HPS occurred or not.Other 35 healthy persons were enrolled as normal controls.The gene polymorphism of HIF-1α C1772T was determined by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP).The correlation between their expressions and the genetic susceptibility of HPS was analyzed.Results The prevalence rate of genotype CC,CT and TT in non-HPS group and HPS group were 1(0.6%),89(48.9%),92(50.5%),and 2(3.2%),37(58.7%),24(38.1%),respectively.In normal control group,only two genotype CC and CT were found,and their prevalence rate were 16(45.7%) and 19(54.3%),respectively.The frequency of C allele and genotype CC+CT was 32.5% and 61.9% in HPS group,significantly differentiated from that in normal control group(22.9%,45.7%) and non-HPS group(25.0%,49.5%,P0.05),and no statistical difference was found in these two groups(P0.05).The frequency of T allele in group HPS(67.5%) showed significant difference compared with that in non-HPS group(75.0%) or normal control group(75.0%,P0.05).As far as clinical features were concerned,the Child-Pugh ranking of liver function in HPS group was B and C.PV,SV,ST,ascites,concentration of PaO2 and NO were all higher in HPS group than in non-HPS group(P0.05).Conclusions C/T gene polymorphism of HIF-1α is correlated with genetic susceptibility of HPS.The mutation of HIF-1 gene SNP/C1772T is associated with the decrease of risk of HPS." @default.
- W2359920596 created "2016-06-24" @default.
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- W2359920596 date "2010-01-01" @default.
- W2359920596 modified "2023-09-26" @default.
- W2359920596 title "Correlation analysis between hypoxia-inducible factor-1α gene polymorphism and hepatopulmonary syndrome" @default.
- W2359920596 hasPublicationYear "2010" @default.
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