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- W2359921042 abstract "Objective To investigate the mechanism underlying antihypertensive effect of olmesartan medoxomil using proteomics technique in spontaneously hypertensive rat(SHR).Methods Twenty SHR(male and female each in half) aged 12-weeks were randomly divided into control and olmesartan medoxomil group.The control group were treated with 0.9% saline by gavaged,while the olmesartan medoxomil group were given suspension made with olmesartan by gavage.After 4 weeks,serum was seperated in low-temperature.Five serum samples from each group were used for two-dimensional gel electrophoresis,then analysised by Imagemaster 5.0 software,and the peptide mass was determined by fingerprinting using MALDI-TOF-MS.The differentially expressed proteins were identified by the matching and comparing the information with database.Results Two-dimensional gel electrophoresis of serum protein were successfully built in control and olmesartan medoxomil group.The average target protein points in two groups were 476±30 and 508±55.There were 20 significantly different points.Compared with control group,13 enhanced expression,5 reduced expression,and 2 were lost in olmesartan medoxomil group.Of 20 protein points,8 were identified by MS as mitochondrial membrane protein,zinc finger protein,T cell receptor and hypothetical proteins.Conclusion The antihypertensive mechanism of olmesartan medoxomil may relate to high expression of inner membrane mitochondrial protein,zinc finger protein,T cell receptor,as well as low expression of retinol-binding protein and Rho GTPase." @default.
- W2359921042 created "2016-06-24" @default.
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- W2359921042 date "2010-01-01" @default.
- W2359921042 modified "2023-09-23" @default.
- W2359921042 title "The Effect of Olmesartan Medoxomil on Serum Protein Expression of Spontaneously Hypertensive Rats" @default.
- W2359921042 hasPublicationYear "2010" @default.
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