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- W2359927722 abstract "OBJECTIVE: To study the effects of different penetration enhancers on transdermal penetration of silk fibroin membrane of cyclosporine A nanoparticles (CyA-NP) in vitro, and to select optimal penetration enhancers. METHODS: The membrane of CyA-NP was prepared with different concentrations of azone, oleic acid, lauryl alcohol, propylene glycol, urea alone and combination of azone with other excipients as penetration enhancers. Using modified Franz diffusion cell, isolated rat abdominal skin as transdermal barrier in vitro,40% ethanol-normal saline as reception fluid, the concentration of CyA in reception fluid was determined by HPLC. The cumulative permeation quantity (Q), steady-state penetrating rate (Js) and enchancement ratio (ER) of CyA were compared in different penetration enhancers. RESULTS:Azone, lauryl alcohol, propylene glycol, urea enhanced the transdermal penetration of the membrane of CyA-NP. The highest permeation rate was obtained in mixture of 1% azone and 2% propylene glycol. The cumulative permeation quantity in 24 h was 2.81 times compared with the membrane without penetration enhancer. The steady-state penetrating rate (Js) was about 6.59 μg·cm-2·h-1 and enchancement ratio (ER) was 2.59. CONCLUSION: Combination of 1% azone with 2% propylene glycol is suitable penetration enhancer for the silk fibroin membrane of CyA-NP." @default.
- W2359927722 created "2016-06-24" @default.
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- W2359927722 date "2011-01-01" @default.
- W2359927722 modified "2023-09-23" @default.
- W2359927722 title "Influence of Different Penetration Enhancers on in Vitro Transdermal Penetration of Silk Fibroin Membrane of Cyclosporine A Nanoparticles" @default.
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