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- W2359940219 abstract "Objective To detect the existence of intrahepatic stem cells in hepatocellular carcinoma and the expression of p53 in intrahepatic stem cells and tumor cells.Methods Immunohistochemistry was performed on 117 paraffin-embedded hepatocellular carcinoma specimens with the marker of hepatocyte and hepatocelluar carcinoma(HepParl),the intrahepatic stem cell specific markers(OV-6,CD56),and p53 protein.Results The intrahepatic stem cells,small epithelial cells with an oval nucleus and scant cytoplasm,with a higher nuclear/cytoplasmic ratio than normal duct cells,were occasionally found and scattered in the tumor tissues without a specific predilection,or existed many proliferating tubular or bilayered structures without obvious lumens lined by duct-like cells in the portal tracts around the edge of tumor nodules.Intrahepatic stem cells were identified with HepParl and OV-6 positive.The tumor cells were HepParl positive and OV-6 negative.In 117 hepatocellular carcinoma samples,38 samples were p53 overexpressed in tumor cells and 36 in intrahepatic stem cells,which were correlated(Kappa=0.526,P=0.000).Conclusion Human hepatocellular carcinogenisis might be based on transformation of intrahepatic stem cells,which had accumulated oncogenic insults over time." @default.
- W2359940219 created "2016-06-24" @default.
- W2359940219 creator A5068016099 @default.
- W2359940219 date "2011-01-01" @default.
- W2359940219 modified "2023-09-23" @default.
- W2359940219 title "The Expression of p53 in Intrahepatic Stem Cell in Hepatocellular Carcinoma" @default.
- W2359940219 hasPublicationYear "2011" @default.
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