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- W2359952086 abstract "Objective To examine the level of human 8-hydroxy-2-desoxyguanosine(8-OHdG) and human 8-hydroxyl guanine DNA glycosidase enzymes(hOGG1) among the residents chronically exposed to low-dose continuous terrestrial radiation. Methods 50 residents age from 50 to 59 years old in Yangjiang high background radiation area(HBRA) were selected as the exposed group and the other 50 residents in neighboring Enping control area(CA) as the control group.10 ml peripheral blood was drawn from each subject and the expression level of 8-OHdG and the mRNA expression level of gene hOGG1 were determined with the method of ELISA and Real-time Quantitative PCR Detecting System(QPCR) respectively.Student's t-test was used to compare with the levels between the exposed and control groups. Results The concentration of 8-OHdG were(270.98±107.46) and(315.39±111.87) μg/L in HBRA and CA respectively.The mRNA relative expression quantity(ΔCt)of genes hOGG1 were(10.31±4.73) and(10.58±4.36) in HBRA and CA respectively.Compared with CA,the concentration of 8-OHdG was lower in HBRA(P0.05) and the mRNA expression level of gene hOGG1 was higher in HBRA(P0.05). Conclusion It is inferred that the capacity of DNA oxidative damage repair may be enhanced with chronic exposure to low-dose radiation." @default.
- W2359952086 created "2016-06-24" @default.
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- W2359952086 date "2012-01-01" @default.
- W2359952086 modified "2023-09-27" @default.
- W2359952086 title "Level of 8-OHdG and hOGG1 among the residents in Yangjiang high background radiation area" @default.
- W2359952086 hasPublicationYear "2012" @default.
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