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- W2359954365 abstract "Objective To explore an optimal regimen of remifentanil-midazolam for analgesia and sedation during minor surgery under local anesthesia.Methods One hundred and seventy-two adult patients scheduled for elective surgery under local anesthesia were randomly assigned to four groups of group R0.0375,R0.05,R0.0625 and D recived remifentanil 0.0375,0.05,0.0625 and 0.075μg·kg-1·min-1,respectively.All patients were sedated with midazolam 0.025mg·kg-1·h-1.During the operation,if the pain score was greater than 3 on the 11-point numeric rating scale(NRS),a bolus of remifentanil 10μg was injected,and if the sedation score was less than 2 on the reversed Observer's Assessment of Alertness/Sedation scale(OAA/S),a bolus of midazolam 0.5mg was injected.Results The incidences of decrease or stop of remifentanil infusion owing to respiratory depression were higher in group R0.0625 and group R0.075 than those in group R0.0375 and group R0.05(P0.05).Oversedation did not occur in any patient.Awareness decreased with the increase of the infusion rate of remifentanil,but there was no statistical difference among group R0.05,R0.0625 and R0.075.Conclusion It is suggested that,on the basis of loading injection of remifentanil 0.5μg/kg and midazolam 0.025mg/kg,midazolam and remifentanil are infused better at the rate of 0.025mg·kg-1·h-1 and 0.05μg·kg-1·min-1,respectively.A bolus of midazolam 0.5mg or remifentanil 10μg is supplemented according to sedative level or pain score." @default.
- W2359954365 created "2016-06-24" @default.
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- W2359954365 date "2008-01-01" @default.
- W2359954365 modified "2023-09-28" @default.
- W2359954365 title "Optimal regimen of remifentanil-midazolam for analgesia and sedation during minor surgery under local anesthesia" @default.
- W2359954365 hasPublicationYear "2008" @default.
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