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- W2359966699 abstract "Objective:To investigate whether administration of an angiotensin converting-enzyme inhibitor (fosinopril ) 24 h before coronary ligation has antiarrythmic effect on reperfusion-induced arrhythmia in rat heart. Method: After the precondition of fosionopri 24 h before, Langendroff reperfusion and floating microelectrode were used to observe the incidence and duration of reperfusion-induced ventriculartachycardia (VT) and ventricular fibrillation (VF) and action potentials(AP)changes in the period of 30 min' reperfusion. Result:The frequency and duration of VT and VF were significantly reduced during 30 min'reperfusion period in fosionopril group ,cardio function was significant improved in fosionopril group. Hoe140, L-NAME and glibenclamide can completely or partly block the antiarrhythmic effect mediated by fosionpril the action potentials parameters were significant improved during 30 min' reperfusion period in fosionopril group. Conclusion: Angiotensin converting-enzyme inhibitor(fosinopril ) pretreatment can offer antiarrhythmia effect on reperfusion-induced VT and VF, the mechanism may involved bradykinin ,NO, K+-ATP and AP." @default.
- W2359966699 created "2016-06-24" @default.
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- W2359966699 date "2004-01-01" @default.
- W2359966699 modified "2023-09-25" @default.
- W2359966699 title "The delayed cardioprotection effect of fosinopril precondition on reperfusion -induced arrhythmias in rat heart" @default.
- W2359966699 hasPublicationYear "2004" @default.
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