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- W2359968135 abstract "The metabonomics method was applied to investigate the effects of nonylphenol(NP) on urine metabolism in Sprague Dawley rat.The profiles of urine samples were obtained with high performance liquid chromatography coupled with time-of-flight mass spectrometry(HPLC/TOF-MS).The data were analyzed with the principle components analysis(PCA) to distinguish the differences of profiles between the NP groups and the control group.The potential biomarkers and effective biomarkers were screened out according to the t-test,and identified with Metlin Scripps Center for mass spectrometry database.The results indicated that the contents of phenyl glucuronide,homocystein,3-nitropropionic acid,creatinine and 5-hydroxytryptamine changed obviously in urine after exposure to NP,which constituted the metabolic profiles in rat urine of NP,and might injury reproductive system,immune system,nervous system and lipometabolism in metabolism process.This study provides the basis for toxicology studies on NP to organisms from the standpoint of metabolism." @default.
- W2359968135 created "2016-06-24" @default.
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- W2359968135 date "2011-01-01" @default.
- W2359968135 modified "2023-09-25" @default.
- W2359968135 title "Metabolic Profiles of Nonylphenol in Rat Urine" @default.
- W2359968135 hasPublicationYear "2011" @default.
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