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- W2359968345 abstract "Objective:To explore the temporal expression of retinal-choroidal transforming growth factor-β2(TGF-β2) in form-deprived myopia(FDM) chick eyes and study the effect of an inhibitor(disulfiram,DSF) of retinoid acid(RA) synthesis on refractive development and the expression of TGF-β2.Methods:Ninety new hatched white leghorn chicks were divided randomly and equally into 3 groups:unilateral occluded with frosted goggles(Group A);unilateral intravitreal injection of 4 mmol of the non-specific aldehydedehydrogenase inhibitor disulfiram with further treatment with goggles(Group B);unilateral intravitreal injections of 4 mmol of disulfiram without further treatment with goggles(Group C).Refraction and axial length were measured on 1,7 and 14 days after treatment.Expression levels of TGF-β2 and TGF-β2 mRNA in the retinal-choroid layer were analyzed by immunohistochemistry and real-time RT-PCR.Results:In Group A,the form-deprived eyes made by goggles developed myopia(P0.05 on day 1,P0.01 on days 7 and 14,compared with the contralateral eyes) with a lengthening of the axial length(P0.01 on days 7 and 14,compared with the contralateral eyes),as well as a lower level of TGF-β2 expression(P0.01 on days 7 and 14,compared with the contralateral eyes).In Groups B and C,there was no statistically significant difference in refraction and axial length between treated and contralateral eyes(P0.05) with TGF-β2 mRNA level growing on day 7 and decreased on day 14 in group B and decreased on day 1,increased on days 7 and 14 in Group C(P0.01,compared with the contralateral eyes).Immunohistochemistry showed that the expression of TGF-β2 was mainly changed in the outer part of photoreceptor layer and retinal pigment epithelium(RPE) layer.Conclusion:TGF-β2 mRNA level dereased in FDM eyes.Disulfiram can up-regulate the level of TGF-β2 mRNA expression in the posterior retional-choroid,and inhibit the elongation of axial length and refractive error made by frosted googles as well.Disulfiram which inhibites the synthesis of retinoid acid may suppress deprivation myopia by up-regulating the expression level of TGF-β2 mRNA." @default.
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- W2359968345 date "2008-12-18" @default.
- W2359968345 modified "2023-09-28" @default.
- W2359968345 title "[Influence of disulfiram on the expression of transforming growth factor-beta2 in form-deprived eyes in chicks]." @default.
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