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- W2359969178 abstract "Objective: To investigate the protective effects and its mechanisms of chuanxiong-pathalide A on the injury of rat cardiac microvascular endothelial cells injury induced by the hypoxia and reoxygenation.Method: The cultured rat microvascular cells were incubated with chuanxiong-pathalide A in the concentrations of 1×10~(-7),1×10~(-9),1×10~(-11) mol·L~(-1) for 55 min,then suffered from hypoxia of 4 hours and reoxygenated of 2 hours.The activity of NO,NOS,ET and the expressions of iNOS mRNA and ET mRNA were observed.Result: Preconditioning with chuanxiong-pathalide A produced an increase in the survival rate of cells and the activitys of NO and NOS,and a decrease ET.Further,preconditioning with chuanxiong-pathalide A induced a high expression of iNOS mRNA and low expression of ET mRNA.Conclusion: The results showed that chuanxiong-pathalide A preconditioning can protect the cardiac microvascular endothelia from the injury caused by the hypoxia and reoxygenation,and the mechanism may be related to the up-regulation of iNOS mRNA expression and down-regulation of ET mRNA expression in the endothelium cell." @default.
- W2359969178 created "2016-06-24" @default.
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- W2359969178 date "2007-01-01" @default.
- W2359969178 modified "2023-09-26" @default.
- W2359969178 title "Protective effect and its mechanism of preconditioning of chuanxiong-pathalide A on rat cardiac microvascular endothelial cell injury by hypoxia and reoxygenation" @default.
- W2359969178 hasPublicationYear "2007" @default.
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