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- W2359969596 abstract "Objective To observe the effects of hepatocyte growth factor(HGF)on vascular endothelial growth factor(VEGF)in ovarian epithelial cancer cells(SKOV3)and its signal transduction pathway.Methods The ovarian cancer cells was treated with HGF at different concentration and for varied time,or treated with Nuclear factor kB(NFkB)inhibitor PDTC.The expression level of VEGF mRNA in the cells was evaluated by relative quantitative reserve-transcription polymerase chain reaction(RT-PCR).Western blot were used to examine VEGF protein and NFkB protein.Results HGF increased the expression of VEGF mRNA and protein in ovarian cancer cell line SKOV3 in dose-and time-dependant manner.Expression of nucleus NFkB protein was increased by HGF in a time-dependant manner and the peak appeared when the cells were treated with HGF for 1 hour.However,PDTC significantly inhibited the expression of NFkB protein induced by HGF.Conclusion HGF modulates the expression of VEGF in ovarian cancer at mRNA and protein level via NFkB pathway." @default.
- W2359969596 created "2016-06-24" @default.
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- W2359969596 date "2005-01-01" @default.
- W2359969596 modified "2023-09-28" @default.
- W2359969596 title "Hhepatocyte growth factor stimulate vascular endothelial growth factor secretion in ovarian cancer cell line and its signal transduction pathway" @default.
- W2359969596 hasPublicationYear "2005" @default.
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