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- W2359969669 abstract "AIM To evaluate the influence of sodium valproate (VPA) on lipid metabolism in epilepsy adult. METHODS This clinical trial was carried out prospective by involving 33 patients with epilepsy adult as trial group and 36 healthy volunteers as control group. Plasma TC, TG, LDL-C, HDL-C, TC / HDL-C, LDL-C / HDL-C, BMI were determined for the control group and also for the trial group before the initiation and at 6 mo after the VPA treatment; and then followed by comparing the correlative parameters between the two groupsand also parameters of the trial group before and after the treatment. RESULTS ( 1) All the pretreatment parameters showed no siginificant difference between the pretreatment parameters of the trial group and the control group (P 0.05),while the levels of TG, TC / HDL-C, LDL-C / HDL-C and BMI in post-treatment parameters of the trial group were significantly higher than those of the control group but the level of HDL-C declined with significant difference (P 0.05, P 0.01) . (2) Comparing the parameters of pretreatment and posttreatment of the trial group showed remarkable increase of TC, LDL-C, TC / HDL-C, LDL-C / HDL-C, BMI and decrease of HDL-C with significant difference (P 0.05, P 0.01) in the post-treatment patients, but no significant difference in TG was shown. (3) There was no significant correlation (P 0.05) between serum lipid spectrum, BMI and various risk factors (including age, sex, mean VPA dosage, etc) before and after VPA treatment. CONCLUSION VPA may induce lipid metabolic disorders and the increment of BMI in epilepsy adult." @default.
- W2359969669 created "2016-06-24" @default.
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- W2359969669 date "2010-01-01" @default.
- W2359969669 modified "2023-09-25" @default.
- W2359969669 title "Effect of sodium valproate on lipid metabolism in epilepsy adult" @default.
- W2359969669 hasPublicationYear "2010" @default.
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