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- W2359974080 abstract "Objective:To observe the expression characteristics of T cell surface molecules and cytokines induced by superantigen(SEA) singly or repeatedly in vitro.Methods:After single(1×) or repeated(n×) induction by SEA in vitro,we examined CD4,CD8,CD69,CD25,CD28 and CTLA-4(CD152) expression on the T lymphocytes by FACS,and determined IL-2,INF-γ,TNF-α,IL-4 and IL-10 production in the supernant.Results:In the group of 1×SEA,the expression of CD4,CD8,CD69,CD25 and CD28 increased significantly,while the expression of CTLA-4(CD152)was low,the production of(IL-2),INF-γ and TNF-α increased quickly.In the group of 2×SEA,there were a little up-regulated expressions of CD4,CD8,CD25 and CD28,and significantly up-regulated expression of CTLA-4 and production of IL-4 and IL-10,whereas the expression of CD69 did not appear to change obviously.In the group of 3×SEA,the expression of CD4,CD8 and CD25 did not increase or decrease obviously,and the expression of CD69,CD28 and CTLA-4 decreased significantly,the production of IL-10 remained up-regulated.Conclusion:The activation and proliferation of naive T cells could be induced by SEA singly,and the T cells became anergic by repeated SEA induction in vitro." @default.
- W2359974080 created "2016-06-24" @default.
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- W2359974080 date "2007-01-01" @default.
- W2359974080 modified "2023-09-26" @default.
- W2359974080 title "Expression characteristics of T cell surface molecules and cytokines induced by superantigen singly or repeatedly" @default.
- W2359974080 hasPublicationYear "2007" @default.
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