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- W2359979160 abstract "Objective To investigate the relationship between the expression of ΔNp73 and the invasiveness of human colon cancer.Methods This study we used LOVO cell,a kind cell of human colon cacinoma cell, as the study objective. ΔNp73 was transferred into LOVO cell by liposome. The effect of ΔNp73 gene on cell growth was detected by trypan blue counter measurement, cell growth curve and flow cytometry, and invasive ability was assessed with Boyden chamber. Western-blot were employed to detect the expression of VEGF.Results The growth of LOVO-ΔNp73 cells were significantly increased,the invasive cell number was significantly larger in LOVO-ΔNp73 cells than in untransfected LOVO cells and LOVO-pcDNA3。The expression of VEGF in the ΔNp73-LOVO was significantly higher than in untransfected LOVO cells(P0.01).Conclusion The overexpression of ΔNp73 promote the proliferation and vessel growth increase the ability of invasion of human colon cancer." @default.
- W2359979160 created "2016-06-24" @default.
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- W2359979160 date "2008-01-01" @default.
- W2359979160 modified "2023-09-23" @default.
- W2359979160 title "Impact of ΔNp73 Expression on Biological Activity of Human Colon Cancer" @default.
- W2359979160 hasPublicationYear "2008" @default.
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