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- W2359985045 abstract "Objective To study the role of the hereditary breast and ovarian cancer susceptibility gene(BRCA1)mutation and estrogen receptor(ER)in breast cancer and study the relationship between BRCA1and ER.Methods64cases with breast cancer were used as the studied group,breast tissues of10cases without cancer were used as the controls.Mutational screening was performed by single-strand conformation polymorphism analysis(SSCP),and alterations were confirmed by DNA sequencing.The estrogen receptors were detected by SP.The BRCA1gene mutations in ER-positive group were compared with those in ER-negative group.Results No mutation was identified in the controls.A total of6single nucleotide changes in BRCA1were identified,all mutations were missense mutations.There were44cases with ER(+),only1case had BRCA1mutation,but there5cases with BRCA1mutation in ER(-)group(5/20).The difference was notable between the two groups.Conclusion BRCA1mutation is related to breast cancer in Guangxi.BRCA1mutations have relation with estrogen receptors.BRCA1-related breast cancers are more frequently estrogen receptor negative than no BRCA1-related breast cancers." @default.
- W2359985045 created "2016-06-24" @default.
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- W2359985045 date "2005-01-01" @default.
- W2359985045 modified "2023-09-23" @default.
- W2359985045 title "BRCA1gene mutations and estrogen receptors in human breast cancer" @default.
- W2359985045 hasPublicationYear "2005" @default.
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