Matches in SemOpenAlex for { <https://semopenalex.org/work/W2359985467> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2359985467 endingPage "222" @default.
- W2359985467 startingPage "217" @default.
- W2359985467 abstract "Objective To study the potential effect of gene-environment interaction between CYP1A1 and serum dichlorodiphenyldichloroethane (DDT) levels on the risk of breast cancer in women,in China. Methods A case-control study was conducted. From Dec. 2003 to Sep. 2004,104 women with histologically confirmed breast cancers and 154 noncancerous controls from a community were enrolled in this study. Risk factors information of breast cancer was investigated by a questionnaire. Serum p,p'- dichlorodiphenyldichloroethane (p,p'-DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p,p'-DDE) levels were tested by GC-ECD. CYP1A1 m2 gene type was tested by allele special-PCR method. Results Serum DDT levels of case and control were ( 36.90± 79.41)ng/ml and ( 50.60± 150.70)ng/ml respectively. Serum 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p,p'-DDE) levels of case and control were ( 7.43± 11.10)ng/ml and ( 8.96± 11.30)ng/ml respectively. No statistically significant differences were found between the two groups with geometric mean t-test ( P 0.05). Compared with women who had homozygous wild-type CYP1A1 m2 genotype,significantly increased risks of breast cancer were found for women with the CYP1A1 m2 homozygous variant genotype [odds ratio (OR)= 2.61,95% confidence interval (CI): 1.00- 6.80]. Among premenopausal women,compared with women with homozygous wild-type of CYP1A1 genotype (Ile/Ile ) and low serum DDT level(DDT serum level ≤ 42.93 ng/ml),women with at least one variant allele of CYP1A1 m2 genotype and high serum DDT level (DDT serum level ≥ 42.93 ng/ml)had higher risk of breast cancer ( OR= 4.35, 95%CI: 1.140- 16.950). Conclusions (43,9CYP1A1 m2 genetic polymorphism was associated with increased risk of female breast cancer while DDT exposure might have increased the risk of breast cancer among premenopausal women with CYP1A1 m2 variant genotype." @default.
- W2359985467 created "2016-06-24" @default.
- W2359985467 creator A5000546208 @default.
- W2359985467 creator A5013069852 @default.
- W2359985467 creator A5019807517 @default.
- W2359985467 creator A5029815331 @default.
- W2359985467 creator A5037968408 @default.
- W2359985467 creator A5050723798 @default.
- W2359985467 creator A5072817423 @default.
- W2359985467 creator A5078726940 @default.
- W2359985467 date "2006-03-01" @default.
- W2359985467 modified "2023-09-29" @default.
- W2359985467 title "[Study on serum organochlorines pesticides (DDTs) level, CYP1A1 genetic polymorphism and risk of breast cancer: a case control study]." @default.
- W2359985467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16792888" @default.
- W2359985467 hasPublicationYear "2006" @default.
- W2359985467 type Work @default.
- W2359985467 sameAs 2359985467 @default.
- W2359985467 citedByCount "6" @default.
- W2359985467 countsByYear W23599854672013 @default.
- W2359985467 countsByYear W23599854672014 @default.
- W2359985467 countsByYear W23599854672019 @default.
- W2359985467 countsByYear W23599854672022 @default.
- W2359985467 crossrefType "journal-article" @default.
- W2359985467 hasAuthorship W2359985467A5000546208 @default.
- W2359985467 hasAuthorship W2359985467A5013069852 @default.
- W2359985467 hasAuthorship W2359985467A5019807517 @default.
- W2359985467 hasAuthorship W2359985467A5029815331 @default.
- W2359985467 hasAuthorship W2359985467A5037968408 @default.
- W2359985467 hasAuthorship W2359985467A5050723798 @default.
- W2359985467 hasAuthorship W2359985467A5072817423 @default.
- W2359985467 hasAuthorship W2359985467A5078726940 @default.
- W2359985467 hasConcept C104317684 @default.
- W2359985467 hasConcept C121608353 @default.
- W2359985467 hasConcept C126322002 @default.
- W2359985467 hasConcept C135763542 @default.
- W2359985467 hasConcept C146304588 @default.
- W2359985467 hasConcept C156957248 @default.
- W2359985467 hasConcept C180754005 @default.
- W2359985467 hasConcept C29456083 @default.
- W2359985467 hasConcept C42407357 @default.
- W2359985467 hasConcept C44249647 @default.
- W2359985467 hasConcept C530470458 @default.
- W2359985467 hasConcept C54355233 @default.
- W2359985467 hasConcept C71924100 @default.
- W2359985467 hasConcept C86803240 @default.
- W2359985467 hasConcept C90924648 @default.
- W2359985467 hasConceptScore W2359985467C104317684 @default.
- W2359985467 hasConceptScore W2359985467C121608353 @default.
- W2359985467 hasConceptScore W2359985467C126322002 @default.
- W2359985467 hasConceptScore W2359985467C135763542 @default.
- W2359985467 hasConceptScore W2359985467C146304588 @default.
- W2359985467 hasConceptScore W2359985467C156957248 @default.
- W2359985467 hasConceptScore W2359985467C180754005 @default.
- W2359985467 hasConceptScore W2359985467C29456083 @default.
- W2359985467 hasConceptScore W2359985467C42407357 @default.
- W2359985467 hasConceptScore W2359985467C44249647 @default.
- W2359985467 hasConceptScore W2359985467C530470458 @default.
- W2359985467 hasConceptScore W2359985467C54355233 @default.
- W2359985467 hasConceptScore W2359985467C71924100 @default.
- W2359985467 hasConceptScore W2359985467C86803240 @default.
- W2359985467 hasConceptScore W2359985467C90924648 @default.
- W2359985467 hasIssue "3" @default.
- W2359985467 hasLocation W23599854671 @default.
- W2359985467 hasLocation W23599854672 @default.
- W2359985467 hasOpenAccess W2359985467 @default.
- W2359985467 hasPrimaryLocation W23599854671 @default.
- W2359985467 hasRelatedWork W1421017940 @default.
- W2359985467 hasRelatedWork W1545877964 @default.
- W2359985467 hasRelatedWork W1979193683 @default.
- W2359985467 hasRelatedWork W1996167019 @default.
- W2359985467 hasRelatedWork W2020370129 @default.
- W2359985467 hasRelatedWork W2091361305 @default.
- W2359985467 hasRelatedWork W2112192811 @default.
- W2359985467 hasRelatedWork W2116066234 @default.
- W2359985467 hasRelatedWork W2129435733 @default.
- W2359985467 hasRelatedWork W2252475886 @default.
- W2359985467 hasRelatedWork W2346730671 @default.
- W2359985467 hasRelatedWork W2348844050 @default.
- W2359985467 hasRelatedWork W2349233450 @default.
- W2359985467 hasRelatedWork W2353648278 @default.
- W2359985467 hasRelatedWork W2358854751 @default.
- W2359985467 hasRelatedWork W2363399604 @default.
- W2359985467 hasRelatedWork W2407955315 @default.
- W2359985467 hasRelatedWork W2417107783 @default.
- W2359985467 hasRelatedWork W2582774392 @default.
- W2359985467 hasRelatedWork W3000069740 @default.
- W2359985467 hasVolume "27" @default.
- W2359985467 isParatext "false" @default.
- W2359985467 isRetracted "false" @default.
- W2359985467 magId "2359985467" @default.
- W2359985467 workType "article" @default.